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The Role of Metal Nanoparticles in the Pathogenesis of Stone Formation.
Labis, Varvara; Gaiduk, Igor; Bazikyan, Ernest; Khmelenin, Dmitry; Zhigalina, Olga; Dyachkova, Irina; Zolotov, Denis; Asadchikov, Victor; Kravtsov, Ivan; Polyakov, Nikita; Solovyev, Andrey; Prusakov, Kirill; Basmanov, Dmitry; Kozlov, Ivan G.
Afiliación
  • Labis V; Department of Surgical Dentistry and Implantology of the N.D. Yushchuk Institute of Continuing Professional Education, Russian University of Medicine of the Ministry of Health of the Russian Federation, 4 Dolgorukovskaya St., 127006 Moscow, Russia.
  • Gaiduk I; Department of Surgical Dentistry and Implantology of the N.D. Yushchuk Institute of Continuing Professional Education, Russian University of Medicine of the Ministry of Health of the Russian Federation, 4 Dolgorukovskaya St., 127006 Moscow, Russia.
  • Bazikyan E; Department of Surgical Dentistry and Implantology of the N.D. Yushchuk Institute of Continuing Professional Education, Russian University of Medicine of the Ministry of Health of the Russian Federation, 4 Dolgorukovskaya St., 127006 Moscow, Russia.
  • Khmelenin D; National Research Centre "Kurchatov Institute", 59 Leninskiy Prospekt, 119333 Moscow, Russia.
  • Zhigalina O; National Research Centre "Kurchatov Institute", 59 Leninskiy Prospekt, 119333 Moscow, Russia.
  • Dyachkova I; National Research Centre "Kurchatov Institute", 59 Leninskiy Prospekt, 119333 Moscow, Russia.
  • Zolotov D; National Research Centre "Kurchatov Institute", 59 Leninskiy Prospekt, 119333 Moscow, Russia.
  • Asadchikov V; National Research Centre "Kurchatov Institute", 59 Leninskiy Prospekt, 119333 Moscow, Russia.
  • Kravtsov I; N.F. Gamaleya Federal Research Center for Epidemiology & Microbiology, 18 Gamalei St., 123098 Moscow, Russia.
  • Polyakov N; N.F. Gamaleya Federal Research Center for Epidemiology & Microbiology, 18 Gamalei St., 123098 Moscow, Russia.
  • Solovyev A; Vernadsky Institute of Geochemistry and Analytical Chemistry of Russian Academy of Sciences, 19 Kosygina St., 119991 Moscow, Russia.
  • Prusakov K; N.F. Gamaleya Federal Research Center for Epidemiology & Microbiology, 18 Gamalei St., 123098 Moscow, Russia.
  • Basmanov D; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.
  • Kozlov IG; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 1A Malaya Pirogovskaya St., 119435 Moscow, Russia.
Int J Mol Sci ; 25(17)2024 Sep 05.
Article en En | MEDLINE | ID: mdl-39273555
ABSTRACT
The process of stone formation in the human body remains incompletely understood, which requires clinical and laboratory studies and the formulation of a new endogenous, nanotechnological concept of the mechanism of origin and formation of crystallization centers. Previously, the mechanism of sialolithiasis was considered a congenital disease associated with the pathology of the ducts in the structure of the glands themselves. To date, such morphological changes of congenital nature can be considered from the position of the intrauterine formation of endogenous bacterial infections complicated by the migration of antigenic structures initiating the formation of crystallization centers. The present work is devoted to the study of the morphology and composition of stones obtained as a result of surgical interventions for sialolithiasis. Presumably, nanoparticles of metals and other chemical compounds can be structural components of crystallization centers or incorporated into the conditions of chronic endogenous inflammation and the composition of antigenic structures, in complexes with protein and bacterial components. X-ray microtomography, X-ray fluorescence analysis, scanning transmission electron microscopy and microanalysis, mass spectrometry, and Raman spectroscopy were used to study the pathogenesis of stone formation. Immunoglobulins (Igs) of classes A and G, as well as nanoparticles of metals Pb, Fe, Cr, and Mo, were found in the internal structure of the stones. The complex of antigenic structures was an ovoid calcified layered matrix of polyvid microbial biofilms, with the inclusion of metal nanoparticles and chemical elements, as well as immunoglobulins. The obtained results of clinical and laboratory studies allow us to broaden the view on the pathogenesis of stone formation and suggest that the occurrence of the calcification of antigenic structures may be associated with the formation of IgG4-associated disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas del Metal Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas del Metal Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2024 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza