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An Abscopal Effect on Lung Metastases in Canine Mammary Cancer Patients Induced by Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic Virus Nanoparticles and Anti-Canine PD-1.
Sergent, Petra; Pinto-Cárdenas, Juan Carlos; Carrillo, Adhara Jaciel Arreguin; Dávalos, Daniel Luna; Pérez, Marisa Daniela González; Lechuga, Dora Alicia Mendoza; Alonso-Miguel, Daniel; Schaafsma, Evelien; Cuarenta, Abigail Jiménez; Muñoz, Diana Cárdenas; Zarabanda, Yuliana; Palisoul, Scott M; Lewis, Petra J; Kolling, Fred W; Affonso de Oliveira, Jessica Fernanda; Steinmetz, Nicole F; Rothstein, Jay L; Lines, Louise; Noelle, Randolph J; Fiering, Steven; Arias-Pulido, Hugo.
Afiliación
  • Sergent P; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
  • Pinto-Cárdenas JC; DIAGSA, Diagnostico de Salud Animal, Naucalpan 53910, Mexico, Mexico.
  • Carrillo AJA; Centro Veterinario Valles, Zapopan 45070, Jalisco, Mexico.
  • Dávalos DL; VETCONNECT Diagnóstico por imagen, Via Toledo, 2952 Mas Palomas, Monterrey 64780, Nuevo León, Mexico.
  • Pérez MDG; Centro Veterinario Valles, Zapopan 45070, Jalisco, Mexico.
  • Lechuga DAM; Centro Veterinario Valles, Zapopan 45070, Jalisco, Mexico.
  • Alonso-Miguel D; Department of Animal Medicine and Surgery, Veterinary Medicine School, Complutense University of Madrid, 28040 Madrid, Spain.
  • Schaafsma E; Aquila Data Analytics, LLC., Concord, NH 03766, USA.
  • Cuarenta AJ; Centro Veterinario Valles, Zapopan 45070, Jalisco, Mexico.
  • Muñoz DC; Centro Veterinario Valles, Zapopan 45070, Jalisco, Mexico.
  • Zarabanda Y; Lab for Vets, Zapopan 45086, Jalisco, Mexico.
  • Palisoul SM; Department of Pathology and Laboratory Medicine at Dartmouth Hitchcock Health, Center for Clinical Genomics and Advanced Technology, Lebanon, NH 03756, USA.
  • Lewis PJ; Department of Radiology Dartmouth Health Geisel School of Medicine, Lebanon, NH 03755, USA.
  • Kolling FW; Dartmouth Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA.
  • Affonso de Oliveira JF; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
  • Steinmetz NF; Moores Cancer Center, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
  • Rothstein JL; Center for Nano-ImmunoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
  • Lines L; Shu and K.C. Chien and Peter Farrell Collaboratory, University of California San Diego, La Jolla, CA 92093, USA.
  • Noelle RJ; Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
  • Fiering S; Moores Cancer Center, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
  • Arias-Pulido H; Center for Nano-ImmunoEngineering, University of California San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Cells ; 13(17)2024 Sep 03.
Article en En | MEDLINE | ID: mdl-39273048
ABSTRACT
Neoadjuvant intratumoral (IT) therapy could amplify the weak responses to checkpoint blockade therapy observed in breast cancer (BC). In this study, we administered neoadjuvant IT anti-canine PD-1 therapy (IT acPD-1) alone or combined with IT cowpea mosaic virus therapy (IT CPMV/acPD-1) to companion dogs diagnosed with canine mammary cancer (CMC), a spontaneous tumor resembling human BC. CMC patients treated weekly with acPD-1 (n = 3) or CPMV/acPD-1 (n = 3) for four weeks or with CPMV/acPD-1 (n = 3 patients not candidates for surgery) for up to 11 weeks did not experience immune-related adverse events. We found that acPD-1 and CPMV/acPD-1 injections resulted in tumor control and a reduction in injected tumors in all patients and in noninjected tumors located in the ipsilateral and contralateral mammary chains of treated dogs. In two metastatic CMC patients, CPMV/acPD-1 treatments resulted in the control and reduction of established lung metastases. CPMV/acPD-1 treatments were associated with altered gene expression related to TLR1-4 signaling and complement pathways. These novel therapies could be effective for CMC patients. Owing to the extensive similarities between CMC and human BC, IT CPMV combined with approved anti-PD-1 therapies could be a novel and effective immunotherapy to treat local BC and suppress metastatic BC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Mamarias Animales / Comovirus / Terapia Neoadyuvante / Nanopartículas / Receptor de Muerte Celular Programada 1 / Inmunoterapia / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Mamarias Animales / Comovirus / Terapia Neoadyuvante / Nanopartículas / Receptor de Muerte Celular Programada 1 / Inmunoterapia / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Revista: Cells Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza