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Haemodynamic Forces: Emerging Markers of Ventricular Remodelling in Multiple Myeloma Cardiovascular Baseline Risk Assessment.
Colomba, Anna; Astarita, Anna; Mingrone, Giulia; Airale, Lorenzo; Catarinella, Cinzia; Vallelonga, Fabrizio; Leone, Dario; Cesareo, Marco; Paladino, Arianna; Bringhen, Sara; Gay, Francesca; Pedrizzetti, Gianni; Veglio, Franco; Milan, Alberto.
Afiliación
  • Colomba A; Department of Medical Sciences, Division of Internal Medicine, Candiolo Cancer Institute FPO-IRCCS, University of Turin, Str.Prov.le 142, km 3,95, 10060 Candiolo, Italy.
  • Astarita A; Hypertension Unit, Department of Medical Sciences, Division of Internal Medicine, AOU Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
  • Mingrone G; Department of Medical Sciences, Division of Internal Medicine, Candiolo Cancer Institute FPO-IRCCS, University of Turin, Str.Prov.le 142, km 3,95, 10060 Candiolo, Italy.
  • Airale L; Hypertension Unit, Department of Medical Sciences, Division of Internal Medicine, AOU Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
  • Catarinella C; Hypertension Unit, Department of Medical Sciences, Division of Internal Medicine, AOU Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
  • Vallelonga F; Department of Medical Sciences, Division of Internal Medicine, Candiolo Cancer Institute FPO-IRCCS, University of Turin, Str.Prov.le 142, km 3,95, 10060 Candiolo, Italy.
  • Leone D; Department of Medical Sciences, Division of Internal Medicine, Candiolo Cancer Institute FPO-IRCCS, University of Turin, Str.Prov.le 142, km 3,95, 10060 Candiolo, Italy.
  • Cesareo M; Hypertension Unit, Department of Medical Sciences, Division of Internal Medicine, AOU Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
  • Paladino A; Department of Medical Sciences, Division of Internal Medicine, Candiolo Cancer Institute FPO-IRCCS, University of Turin, Str.Prov.le 142, km 3,95, 10060 Candiolo, Italy.
  • Bringhen S; SSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, AOU Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
  • Gay F; SSD Clinical Trial in Oncoematologia e Mieloma Multiplo, Division of Hematology, AOU Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
  • Pedrizzetti G; Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Torino, 10124 Turin, Italy.
  • Veglio F; Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy.
  • Milan A; Hypertension Unit, Department of Medical Sciences, Division of Internal Medicine, AOU Città della Salute e della Scienza University Hospital, 10126 Turin, Italy.
Cancers (Basel) ; 16(17)2024 Sep 04.
Article en En | MEDLINE | ID: mdl-39272939
ABSTRACT
Multiple myeloma (MM) affects a population with a high prevalence of cardiovascular (CV) disease. These patients benefit from an accurate CV risk evaluation in order to choose the safest drug regimen. Haemodynamic forces (HDFs) analysis allows for the earlier detection of myocardial damage compared with standard markers; the role played by MM in HDFs alteration, with or without the influence of hypertension, is yet to be studied. Therefore, we aimed to identify differences in HDFs analysis in patients with MM, hypertension or both versus normotensive non-oncologic subjects. A total of 173 patients (MM hypertensive patients, MMHT; MM normotensive patients, MMNT; non-oncologic hypertensive patients, CoHT; and non-oncologic normotensive patients, CoNT) underwent transthoracic echocardiography for HDFs analysis and pulse wave velocity (PWV) assessment. Hypertensive patients (MMHT, CoHT) showed decreased ejection fraction (EF), global longitudinal strain (GLS) and HDFs values compared with CoNT, whereas ventricular mass (LVMi) and PWV increased. MMNT displayed a significant reduction in systolic HDFs (p < 0.006) and systolic ejection HDFs (p < 0.008) compared with CoNT, without significant change in EF, GLS, LVMi or PWV. In conclusion, MM leads to ventricular remodelling regardless of hypertension; HDFs application for MM patients could help detect early myocardial damage, especially in patients receiving cardiotoxic drugs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza