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ROS exhaustion reverses the effects of hyperbaric oxygen on hemorrhagic transformation through reactivating microglia in post-stroke hyperglycemic mice.
Guo, Yanan; Liu, Jiayi; Du, Xingyue; Qi, Mian; She, Tongping; Xue, Ke; Wu, Xinhe; Xu, Lihua; Peng, Bin; Zhang, Yunfeng; Liu, Yufeng; Jiang, Zhenglin; Li, Xia; Yuan, Yuan.
Afiliación
  • Guo Y; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Liu J; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Du X; Jiang'an Health Institute of Rugao Municipal Health Commission, Nantong, 226534, China.
  • Qi M; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • She T; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Xue K; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Wu X; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Xu L; The Second People's Hospital of Nantong, Nantong, 226002, China.
  • Peng B; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Zhang Y; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Liu Y; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Jiang Z; The Second People's Hospital of Nantong, Nantong, 226002, China.
  • Li X; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China.
  • Yuan Y; Institute of Special Environmental Medicine, Affiliated Hospital of Nantong University, Nantong University, Nantong, 226001, China. lixia7979@ntu.edu.cn.
Sci Rep ; 14(1): 21410, 2024 09 13.
Article en En | MEDLINE | ID: mdl-39271781
ABSTRACT
Acute ischemic stroke (AIS) is a major global health concern due to its high mortality and disability rates. Hemorrhagic transformation, a common complication of AIS, leads to poor prognosis yet lacks effective treatments. Preclinical studies indicate that hyperbaric oxygen (HBO) treatment within 12 h of AIS onset alleviates ischemia/reperfusion injuries, including hemorrhagic transformation. However, clinical trials have yielded conflicting results, suggesting some underlying mechanisms remain unclear. In this study, we confirmed that HBO treatments beginning within 1 h post reperfusion significantly alleviated the haemorrhage and neurological deficits in hyperglycemic transient middle cerebral arterial occlusion (tMCAO) mice, partly due to the inhibition of the NLRP3 inflammasome-mediated pro-inflammatory response in microglia. Notably, reactive oxygen species (ROS) mediate the anti-inflammatory and protective effect of early HBO treatment, as edaravone and N-Acetyl-L-Cysteine (NAC), two commonly used antioxidants, reversed the suppressive effect of HBO treatment on NLRP3 inflammasome-mediated inflammation in microglia. Furthermore, NAC countered the protective effect of early HBO treatment in tMCAO mice with hyperglycemia. These findings support that early HBO treatment is a promising intervention for AIS, however, caution is warranted when combining antioxidants with HBO treatment. Further assessments are needed to clarify the role of antioxidants in HBO therapy for AIS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Especies Reactivas de Oxígeno / Microglía / Oxigenoterapia Hiperbárica / Hiperglucemia Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Especies Reactivas de Oxígeno / Microglía / Oxigenoterapia Hiperbárica / Hiperglucemia Límite: Animals Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido