IL-17 family cytokines in inflammatory or autoimmune skin diseases.

Kong, Baida; Lai, Yuping

Kong, Baida; Lai, Yuping.

Afiliación

Kong B; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, P.R. China; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, School of Life Sciences, East China Normal University, Shanghai, P.R. China.
Lai Y; Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, P.R. China; Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, School of Life Sciences, East China Normal University, Shanghai, P.R. China. Electronic address: yplai@bio.ecnu.edu.cn.

Adv Immunol ; 163: 21-49, 2024.

Article en En | MEDLINE | ID: mdl-39271258

ABSTRACT

ABSTRACT

As potent pro-inflammatory mediators, IL-17 family cytokines play crucial roles in the pathogenesis of various inflammatory and autoimmune skin disorders. Although substantial progress has been achieved in understanding the pivotal role of IL-17A signaling in psoriasis, leading to the development of highly effective biologics, the functions of other IL-17 family members in inflammatory or autoimmune skin diseases remain less explored. In this review, we provide a comprehensive overview of IL-17 family cytokines and their receptors, with a particular focus on the recent advancements in identifying cellular sources, receptors and signaling pathways regulated by these cytokines. At the end, we discuss how the aberrant functions of IL-17 family cytokines contribute to the pathogenesis of diverse inflammatory or autoimmune skin diseases.

Asunto(s)

Enfermedades Autoinmunes; Interleucina-17; Transducción de Señal; Enfermedades de la Piel; Humanos; Interleucina-17/metabolismo; Interleucina-17/inmunología; Enfermedades Autoinmunes/inmunología; Enfermedades Autoinmunes/metabolismo; Animales; Enfermedades de la Piel/inmunología; Enfermedades de la Piel/metabolismo; Psoriasis/inmunología; Psoriasis/metabolismo; Inflamación/inmunología; Inflamación/metabolismo; Receptores de Interleucina-17/metabolismo; Receptores de Interleucina-17/inmunología

Palabras clave

IL-17 family cytokines; Inflammatory/autoimmune skin disorders; Receptors for IL-17 cytokines; Signaling transduction

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de la Piel / Enfermedades Autoinmunes / Transducción de Señal / Interleucina-17 Límite: Animals / Humans Idioma: En Revista: Adv Immunol Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos

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