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Density of fresh wall of acute aortic dissection with synchrotron-based x-ray phase tomography.
Yokawa, Koki; Hoshino, Masato; Yagi, Naoto; Nakashima, Yutaka; Nakagawa, Kazunori; Okita, Yutaka; Okada, Kenji; Tsukube, Takuro.
Afiliación
  • Yokawa K; Division of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Hoshino M; Research & Utilization Division, Japan Synchrotron Radiation Research Institute/SPring-8, Sayo, Hyogo, Japan.
  • Yagi N; Research & Utilization Division, Japan Synchrotron Radiation Research Institute/SPring-8, Sayo, Hyogo, Japan.
  • Nakashima Y; Division of Pathology, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
  • Nakagawa K; Pathophysiological and Experimental Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
  • Okita Y; Division of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
  • Okada K; Division of Cardiovascular Surgery, Takatsuki General Hospital, Takatsuki, Japan.
  • Tsukube T; Division of Cardiovascular Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Interdiscip Cardiovasc Thorac Surg ; 2024 Sep 13.
Article en En | MEDLINE | ID: mdl-39271147
ABSTRACT

OBJECTIVES:

The mechanisms behind the onset of acute aortic dissection have not been fully elucidated. We developed dynamic Synchrotron-based X-ray phase tomography to quantitatively study the dynamics of biological samples and applied it to the fresh aortic wall in acute type-A aortic dissection.

METHODS:

Fresh, ring-shaped aortas undergoing aortic repair in acute type-A aortic dissection were measured in a container filled with normal cold saline within 24 hours of surgery. As a control, we obtained five formalin-fixed normal ascending aortas from autopsies (female 2, 59.7 (SD 5.5) years). To evaluate the quantitative morphological change, we estimated the density at five each step stretched by 2 mm per step. The fresh specimens were analyzed pathologically about the area ratio of elastic fibre.

RESULTS:

Samples were obtained from five patients (1 man and 4 women, 59.4 (SD 8.7) years) The overall density of the tunica media in the fresh aorta was 1.062(SD 0.006) g/cm3 and differed significantly between the dissected and non-dissected portion (1.05(SD 0.004) vs 1.066(SD 0.004) g/cm3, respectively; p = 0.0122). When the fresh aortic wall was stretched and became thinner, the density of the tunica media remained unchanged. Compared with pathological findings, area ratio of the elastic fibre of the tunica media were lower in non-dissected portion than normal (48.6 (SD 7.1) % v.s 60.5 (SD 5.7) %, p < 0.001).

CONCLUSIONS:

Dynamic-XPCT can trace the deformation process that occurs in situ in fresh aorta in acute type-A aortic dissection. We confirmed that densitometric property of the aortic wall in acute type-A aortic dissection was unchanged during the stretching process.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Interdiscip Cardiovasc Thorac Surg Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Interdiscip Cardiovasc Thorac Surg Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido