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Feeding parenteral nutrition in the neonatal period programs dyslipidemia in adulthood in Yucatan miniature pigs.
Randunu, Raniru S; Alawaini, Khaled; Huber, Lee-Anne; Randell, Edward W; Brunton, Janet A; Bertolo, Robert F.
Afiliación
  • Randunu RS; Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada.
  • Alawaini K; Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada.
  • Huber LA; Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada.
  • Randell EW; Discipline of Laboratory Medicine, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
  • Brunton JA; Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada.
  • Bertolo RF; Department of Biochemistry, Memorial University of Newfoundland, St. John's, NL, Canada. Electronic address: rbertolo@mun.ca.
J Nutr ; 2024 Sep 11.
Article en En | MEDLINE | ID: mdl-39270853
ABSTRACT

BACKGROUND:

Early nutritional challenges can lead to permanent metabolic changes, increasing risk for developing chronic diseases later in life. Total parenteral nutrition (TPN) is a life-saving nutrition regimen, used especially in intrauterine growth-restricted (IUGR) neonates. Early TPN feeding alters metabolism, but whether these alterations are permanent is unclear. Programmed metabolism is likely caused by epigenetic changes due to imbalances of methyl nutrients.

OBJECTIVES:

We sought to determine whether feeding TPN in early life would increase the risk of developing dyslipidemia in adulthood and whether supplementing the methyl nutrients betaine and creatine to TPN would prevent this development. We also sought to determine whether IUGR exacerbates the effects of neonatal TPN on lipid metabolism in adulthood.

METHODS:

Female piglets (n=32, 7 d old) were used in four treatments 24 normal weight piglets were randomized to sow-fed (SowFed), standard TPN (TPN-control), and TPN with betaine and creatine (TPN-B+C); 8 IUGR piglets were fed control TPN (TPN-IUGR) as a fourth group. After 2 weeks of treatment, all pigs were then fed a standard solid diet. At 8 mo old, central venous catheters were implanted to conduct postprandial fat tolerance tests.

RESULTS:

Feeding TPN in the neonatal period led to dyslipidemia in adulthood, as indicated by higher postprandial triglyceride (TG) levels in TPN-control (P<0.05), compared to SowFed. IUGR piglets were particularly sensitive to neonatal TPN feeding, as TPN-IUGR piglets developed obesity and dyslipidemia in adulthood, as indicated by greater backfat thickness (P<0.05), higher liver TG (P<0.05), slower postprandial TG clearance (P<0.05), and elevated fasting plasma non-high density lipoprotein (HDL)-cholesterol (P<0.01), and non-esterified fatty acids (NEFA) (P<0.001), compared to TPN-control.

CONCLUSIONS:

Feeding TPN in early life increases the risk of developing dyslipidemia in adulthood, especially in IUGR neonates; however, methyl nutrient supplementation to TPN did not prevent TPN-induced changes in lipid metabolism.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Nutr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Nutr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos