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Positronium image of the human brain in vivo.
Moskal, Pawel; Baran, Jakub; Bass, Steven; Choinski, Jaroslaw; Chug, Neha; Curceanu, Catalina; Czerwinski, Eryk; Dadgar, Meysam; Das, Manish; Dulski, Kamil; Eliyan, Kavya V; Fronczewska, Katarzyna; Gajos, Aleksander; Kacprzak, Krzysztof; Kajetanowicz, Marcin; Kaplanoglu, Tevfik; Kaplon, Lukasz; Klimaszewski, Konrad; Kobylecka, Malgorzata; Korcyl, Grzegorz; Kozik, Tomasz; Krzemien, Wojciech; Kubat, Karol; Kumar, Deepak; Kunikowska, Jolanta; Maczewska, Joanna; Migdal, Wojciech; Moskal, Gabriel; Mryka, Wiktor; Niedzwiecki, Szymon; Parzych, Szymon; Del Rio, Elena P; Raczynski, Lech; Sharma, Sushil; Shivani, Shivani; Shopa, Roman Y; Silarski, Michal; Skurzok, Magdalena; Tayefi, Faranak; Ardebili, Keyvan T; Tanty, Pooja; Wislicki, Wojciech; Królicki, Leszek; Stepien, Ewa L.
Afiliación
  • Moskal P; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Baran J; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Bass S; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Choinski J; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Chug N; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Curceanu C; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Czerwinski E; Kitzbühel Centre for Physics, Kitzbühel, Austria.
  • Dadgar M; Heavy Ion Laboratory, University of Warsaw, Warsaw, Poland.
  • Das M; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Dulski K; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Eliyan KV; INFN, Laboratori Nazionali di Frascati, Via E. Fermi 40, 00044 Frascati, Italy.
  • Fronczewska K; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Gajos A; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Kacprzak K; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Kajetanowicz M; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Kaplanoglu T; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Kaplon L; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Klimaszewski K; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Kobylecka M; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Korcyl G; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Kozik T; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Krzemien W; Department of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.
  • Kubat K; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Kumar D; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Kunikowska J; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Maczewska J; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Migdal W; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Moskal G; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Mryka W; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Niedzwiecki S; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Parzych S; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Del Rio EP; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Raczynski L; Department of Complex Systems, National Centre for Nuclear Research, 05-400 Otwock-Swierk, Poland.
  • Sharma S; Department of Nuclear Medicine, Medical University of Warsaw, Banacha 1a, 02-097 Warsaw, Poland.
  • Shivani S; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Shopa RY; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Silarski M; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Skurzok M; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Tayefi F; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Ardebili KT; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Tanty P; High Energy Department, National Centre for Nuclear Research, 05-400 Otwock-Swierk, Poland.
  • Wislicki W; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
  • Królicki L; Centre for Theranostics, Jagiellonian University, Kopernika 40, 31-501 Krakow, Poland.
  • Stepien EL; Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, S. Lojasiewicza 11, 30-348 Krakow, Poland.
Sci Adv ; 10(37): eadp2840, 2024 Sep 13.
Article en En | MEDLINE | ID: mdl-39270027
ABSTRACT
Positronium is abundantly produced within the molecular voids of a patient's body during positron emission tomography (PET). Its properties dynamically respond to the submolecular architecture of the tissue and the partial pressure of oxygen. Current PET systems record only two annihilation photons and cannot provide information about the positronium lifetime. This study presents the in vivo images of positronium lifetime in a human, for a patient with a glioblastoma brain tumor, by using the dedicated Jagiellonian PET system enabling simultaneous detection of annihilation photons and prompt gamma emitted by a radionuclide. The prompt gamma provides information on the time of positronium formation. The photons from positronium annihilation are used to reconstruct the place and time of its decay. In the presented case study, the determined positron and positronium lifetimes in glioblastoma cells are shorter than those in salivary glands and those in healthy brain tissues, indicating that positronium imaging could be used to diagnose disease in vivo.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Glioblastoma / Tomografía de Emisión de Positrones Límite: Humans Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Neoplasias Encefálicas / Glioblastoma / Tomografía de Emisión de Positrones Límite: Humans Idioma: En Revista: Sci Adv Año: 2024 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos