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Environmental arsenic exposure and reproductive system toxicity in male and female and mitigatory strategies: a review.
Eslami, Hadi; Askari, Foad Ranjbar; Mahdavi, Masoumeh; Taghavi, Mahmoud; Ghaseminasab-Parizi, Maryam.
Afiliación
  • Eslami H; Occupational Environment Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. H.eslami@rums.ac.ir.
  • Askari FR; Department of Environmental Health Engineering, School of Health, Occupational Safety and Health Research Center, NICICO, World Safety Organization and Rafsanjan University of Medical Sciences, Rafsanjan, Iran. H.eslami@rums.ac.ir.
  • Mahdavi M; Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
  • Taghavi M; Student Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
  • Ghaseminasab-Parizi M; Department of Environment Health Engineering, School of Health, Social Determinates of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.
Environ Geochem Health ; 46(10): 420, 2024 Sep 13.
Article en En | MEDLINE | ID: mdl-39269655
ABSTRACT
Environmental Arsenic (As) exposure is one of the main health challenges in different area of the world. As is a significant factor responsible to the reproductive system toxicity in both male and female. In this study, the most important effects mechanisms and biomarkers related to environmental exposure to As and the reproductive system toxicity, and infertility risk are reviewed in male and female. The results showed that the most important As-induced reproductive system toxicity in the male were alteration in the quantity and quality of semen, testicular toxicity, oxidative stress, testosterone reduction, and sperm apoptosis. For female were oxidative stress, spontaneous miscarriage, reproductive cycle disruption, decrease in the estradiol, progesterone, and testosterone levels and impair fecundity. The main mechanisms of reproductive system toxicity caused by As exposure in male were, genotoxic effects, reduction of glutathione, disruption of sex hormones, sperm flagellum formation impairment, inhibition of spermatogenesis, disruption of cell signaling pathways, and metabolites disruption. For female were abnormal signaling in gene expression, hormonal homeostasis, As-accumulation in placental tissue and creation of reactive oxygen, disruption in the neurotransmitters balance, and sex hormones disruption. The suitable biomarkers for As-induced reproductive toxicity in male were changes in testosterone, one-carbon and lipid metabolism, noncoding RNAs, and steroid hormone homeostasis, and for female was human chorionic gonadotropin (hCG) changes. Finaly, taking selenium, zinc, silymarin, vitamins (C and E) and phytonutrients can be effective in reducing the As-induced reproductive system toxicity and infertility risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Reproducción / Exposición a Riesgos Ambientales Límite: Female / Humans / Male Idioma: En Revista: Environ Geochem Health Asunto de la revista: QUIMICA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arsénico / Reproducción / Exposición a Riesgos Ambientales Límite: Female / Humans / Male Idioma: En Revista: Environ Geochem Health Asunto de la revista: QUIMICA / SAUDE AMBIENTAL Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos