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Thyroid autoimmunity is associated with dietary fat consumption.
Xu, Lulian; Liu, Zhenzhen; Xu, Xu; Wan, Qiwen; Zhen, Juanying; Jiang, Li; Cheung, Bernard Man Yung; Li, Chao.
Afiliación
  • Xu L; Department of Pediatric Endocrinology, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
  • Liu Z; Department of Pediatric Endocrinology, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
  • Xu X; Department of Pediatric Endocrinology, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
  • Wan Q; Department of Pediatric Neurosurgery, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
  • Zhen J; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR.
  • Jiang L; Department of Pediatric Endocrinology, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China.
  • Cheung BMY; Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong SAR.
  • Li C; State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Pokfulam, Hong Kong SAR.
J Clin Endocrinol Metab ; 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39268914
ABSTRACT
CONTEXT Dietary factors are crucial in the onset and development of autoimmune thyroid disease (AITD), but the relationship between specific fatty acids and AITD remains unexplored.

METHODS:

We analyzed the US National Health and Nutrition Examination Survey (NHANES) 2007-2012 data on 3949 men and 3964 women aged 20 years and over with valid data on TPOAb, TgAb and details of fat intake, using multivariable regression models to examine the relationship of fat intake and specific fatty acid intake with thyroid autoimmunity.

RESULTS:

Of the 7913 participants, 7.5% had TgAb seropositivity and 11.9% had TPOAb seropositivity. The seropositivity of TgAb and TPOAb was more common in low-fat intake participants. In the overall population and men, fats were associated with thyroid autoimmunity before and after full adjustment for age, ethnicity, body mass index, smoking status and urine iodine concentration (total fat OR=0.64, 95% CI 0.49 to 0.83; SFA OR=0.65, 95% CI 0.51 to 0.84; MUFA OR=0.65, 95% CI 0.50 to 0.85; PUFA OR=0.76, 95% CI 0.57 to 0.995, after full adjustment in men). Some specific fatty acids followed a similar pattern. The association between fats and TgAb seropositivity was significant in the overall population and men. The association between fats and TPOAb seropositivity was only found in the overall population.

CONCLUSION:

We found a strong association between fat consumption and thyroid autoimmunity in the overall population and men from the nationally representative population-based survey. Fat and fatty acid consumption may be of benefit to individuals with thyroid autoimmunity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Clin Endocrinol Metab Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos