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Berberine attenuates TNBS-induced colitis in mice by improving the intestinal microbiota.
Li, Chao; Yin, Xinxin; Xie, Changpeng; Zeng, Jin; Song, Chuan; Yang, Guibin; Zhang, Jinglei; Chen, Siai; Wei, Panjian; Wang, Ziyu; Gu, Meng; Li, Wei; An, Juan; Pan, Yuanming.
Afiliación
  • Li C; Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • Yin X; Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.
  • Xie C; Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.
  • Zeng J; Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.
  • Song C; Department of Gastroenterology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, China.
  • Yang G; Department of Gastroenterology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, China.
  • Zhang J; Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.
  • Chen S; Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.
  • Wei P; Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
  • Wang Z; Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
  • Gu M; Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
  • Li W; Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
  • An J; Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.
  • Pan Y; Cancer Research Center, Beijing Chest Hospital, Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Front Microbiol ; 15: 1463005, 2024.
Article en En | MEDLINE | ID: mdl-39268532
ABSTRACT

Objective:

To investigate the effects of berberine (BBR) as a treatment on intestinal microecological alterations and enteritis in mice produced by TNBS.

Methods:

There were seven mice per group seven in the healthy group (Ctrl), seven in the TNBS-induced enteritis group (TNBS), and seven in the berberine treatment group (BBR). The mice were weighed, slaughtered after 7 days, and subjected to high-throughput intestinal microecological analysis by Illumina, as well as haematological detection and imaging evaluation of colon pathology.

Results:

The alterations in colon length, immune cell subpopulations, inflammatory factors, and intestinal microecology of mice induced by BBR were refined using a battery of experiments and observations. According to intestinal microecological studies, BBR can increase the number of bacteria, including Lactobacillus, Verrucomicrobia, Bacteroides, and Akkermansia muciniphila.

Conclusion:

BBR has a therapeutic effect on TNBS-induced colitis in mice, which is associated with modifications in immune cell subpopulations and intestinal microecology. It also offers a viable approach as a prospective probiotic (like Akkermansia muciniphila) to IBD therapy in clinical settings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Microbiol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza