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Investigating the combinatorial effects of radiofrequency ablation and anticoagulants in patients with atrial fibrillation and left atrial appendage thrombosis after successful thrombolysis.
Sun, Yuzhang; Hu, Xiaofeng; Xu, Changhao; Zhang, Menghe; Wu, Shaohui; Qin, Mu; Liu, Xu; Dong, Yujiang.
Afiliación
  • Sun Y; Graduate School, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.
  • Hu X; Department of Cardiology, Shanghai Jiao Tong University Affiliated Chest Hospital, Shanghai 200030, P.R. China.
  • Xu C; Department of Cardiology, Shanghai Jiao Tong University Affiliated Chest Hospital, Shanghai 200030, P.R. China.
  • Zhang M; Department of Cardiology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.
  • Wu S; Department of Cardiology, Shanghai Jiao Tong University Affiliated Chest Hospital, Shanghai 200030, P.R. China.
  • Qin M; Department of Cardiology, Shanghai Jiao Tong University Affiliated Chest Hospital, Shanghai 200030, P.R. China.
  • Liu X; Department of Cardiology, Shanghai Jiao Tong University Affiliated Chest Hospital, Shanghai 200030, P.R. China.
  • Dong Y; Graduate School, Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250355, P.R. China.
Exp Ther Med ; 28(5): 407, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39268372
ABSTRACT
The present study investigated the synergistic effects of radiofrequency ablation and various anticoagulants on adverse outcomes in patients with atrial fibrillation (AF) and left atrial appendage thrombosis following successful thrombolysis. Patients diagnosed with AF and left atrial appendage thrombosis post-successful thrombolysis (n=92) were retrospectively analysed. They were divided into two groups Group A received radiofrequency ablation combined with an anticoagulant, while Group B received an anticoagulant alone and in combination with antiarrhythmic drugs. Subgroup analyses were conducted based on left atrial diameter (>45 mm), duration of AF (>1 year) and types of anticoagulants. Univariate and multivariate logistic regression analyses were performed to assess stroke and mortality risks in patients with AF with left atrial appendage thrombosis after dissolution. Multivariate logistic regression analysis identified AF duration (>1 year), left atrial diameter (>45 mm) and BNP level as significant risk factors for stroke (P<0.05). Compared with NOACs, the traditional anticoagulants (warfarin) demonstrated higher survival rates and lower stroke incidence in Group B (P<0.05); however, no significant difference was observed within Group A (P>0.05). Radiofrequency ablation combined with anticoagulants appeared to be more effective in treating AF with left atrial appendage thrombosis post-dissolution compared with anticoagulants alone. Attention to AF duration and left atrial diameter is crucial during early patient management. However, the choice between warfarin or NOACs for patients with AF and left atrial appendage thrombosis warrants further investigation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Exp Ther Med Año: 2024 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Exp Ther Med Año: 2024 Tipo del documento: Article Pais de publicación: Grecia