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Depression and type 2 diabetes risk: a Mendelian randomization study.
Liu, Kaiyuan; Zhou, Diyi; Chen, Lijun; Hao, Sida.
Afiliación
  • Liu K; Department of Endocrinology, Zhejiang Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou, Zhejiang, China.
  • Zhou D; Department of Endocrinology, Zhejiang Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou, Zhejiang, China.
  • Chen L; Department of Endocrinology, Zhejiang Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou, Zhejiang, China.
  • Hao S; Department of Urology, Zhejiang Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou, Zhejiang, China.
Front Endocrinol (Lausanne) ; 15: 1436411, 2024.
Article en En | MEDLINE | ID: mdl-39268231
ABSTRACT

Background:

Extensive observational evidence has suggested an association between depression and type 2 diabetes (T2D). However, the causal relationships between these two diseases require further investigation. This study aimed to evaluate the bidirectional causal effect between two types of depression and T2D using two-sample Mendelian randomization (MR).

Methods:

We applied two-step MR techniques, using single-nucleotide polymorphisms (SNPs) as the genetic instruments for analysis. We utilized summary data from genome-wide association studies (GWASs) for major depression (MD), depressive status (frequency of depressed mood in the last two weeks), T2D, and other known T2D risk factors such as obesity, sedentary behavior (time spent watching television), and blood pressure. The analysis utilized inverse variance weighted (IVW), MR-Egger regression, weighted median, weighted mode, MR pleiotropy residual sum, and outlier methods to determine potential causal relationships.

Results:

The study found that MD was positively associated with T2D, with an odds ratio (OR) of 1.26 (95% CI 1.10-1.43, p = 5.6×10-4) using the IVW method and an OR of 1.21 (95% CI 1.04-1.41, p = 0.01) using the weighted median method. Depressive status was also positively associated with T2D, with an OR of 2.26 (95% CI 1.03-4.94, p = 0.04) and an OR of 3.62 (95% CI 1.33-9.90, p = 0.01) using the IVW and weighted median methods, respectively. No causal effects of MD and depressive status on T2D risk factors were observed, and T2D did not influence these factors.

Conclusion:

Our study demonstrates a causal relationship between depression and an increased risk of developing T2D, with both major depression and depressive status being positively associated with T2D.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Diabetes Mellitus Tipo 2 / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Diabetes Mellitus Tipo 2 / Estudio de Asociación del Genoma Completo / Análisis de la Aleatorización Mendeliana Límite: Humans Idioma: En Revista: Front Endocrinol (Lausanne) Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza