Your browser doesn't support javascript.
loading
Hepatic mitochondrial and peroxisomal alterations in acutely ill malnourished Malawian children: A postmortem cohort study.
Ling, Catriona M; Sheferaw, Tewabu F; Denno, Donna M; Chasweka, Dennis; Kamiza, Steve B; Ordi, Jaume; Moxon, Christopher A; Kats, Kim; Khoswe, Stanley; Mbale, Emmie; Ziwoya, Frank; Tembo, Abel; Attipa, Charalampos; Potani, Isabel; Kim, Peter K; Berkley, James A; Walson, Judd L; Voskuijl, Wieger P; Bandsma, Robert H J.
Afiliación
  • Ling CM; Department of Nutritional Sciences, University of Toronto, Toronto, Canada.
  • Sheferaw TF; Translational Medicine, The Hospital for Sick Children, Toronto, Canada.
  • Denno DM; Amsterdam UMC location University of Amsterdam, Amsterdam Centre for Global Child Health, Emma Children's hospital, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
  • Chasweka D; Department of Pediatrics, University of Washington, Seattle, Washington, USA.
  • Kamiza SB; The Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
  • Ordi J; Department of Global Health, University of Washington, Seattle, Washington, USA.
  • Moxon CA; The Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
  • Kats K; Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
  • Khoswe S; Department of Pathology, Kumuzu University of Health Sciences, Blantyre, Malawi.
  • Mbale E; Department of Pathology, Hospital Clinic, Universitat de Barcelona, Spain.
  • Ziwoya F; Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
  • Tembo A; Welcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
  • Attipa C; Malawi-Liverpool Wellcome Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Potani I; Department of Biomedical Science of Cells and Systems, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Kim PK; Malawi-Liverpool Wellcome Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Berkley JA; The Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
  • Walson JL; Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
  • Voskuijl WP; Malawi-Liverpool Wellcome Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Bandsma RHJ; The Childhood Acute Illness & Nutrition (CHAIN) Network, c/o KEMRI Wellcome Trust Research Programme, Nairobi, Kenya.
Glob Pediatr ; 9: None, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39267884
ABSTRACT

Objectives:

To describe and compare liver mitochondrial and peroxisomal histopathology by nutritional status in children who died following hospitalization for acute illness in Malawi.

Methods:

Liver tissue was collected using Minimally Invasive Tissue Sampling from eleven children under-five years old who died during hospitalization and were either non-wasted (n = 4), severely wasted (n = 4) or had edematous malnutrition (n = 3). Histology was assessed on hematoxylin and eosin stained slides. Mitochondrial and peroxisomal ultrastructural features were characterized using electron microscopy (EM) and immunofluorescence (IF).

Results:

Hepatic steatosis was present in 50 % of non-wasted and severely wasted children and all children with edematous malnutrition. Edematous malnutrition was associated with 56 % and 45 % fewer mitochondria than severe wasting (p < 0.001) and no wasting (p = 0.006), respectively, and abnormal mitochondrial morphology compared to severe wasting (p = 0.002) and no wasting (p = 0.035). Peroxisomal abundance was reduced in edematous malnutrition compared to severe wasting (p = 0.005), but did not differ from no-wasting.

Conclusion:

Edematous malnutrition is associated with reduced abundance and altered morphology of hepatic mitochondria and peroxisomes. Interventions targeting improvements in hepatic metabolic function may be beneficial in improving metabolism and reducing mortality in children with severe malnutrition, particularly in those with nutritional edema.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Glob Pediatr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Glob Pediatr Año: 2024 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos