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Plasma concentrations of IL-6, MIP-1ß, IP-10, and PTX-3 as predictors of the immunological response to antiretroviral treatment in people with HIV.
Mejías-Trueba, Marta; Saborido-Alconchel, Abraham; Serna-Gallego, Ana; Trujillo-Rodríguez, María; Muñoz-Muela, Esperanza; Llaves-Flores, Silvia; Espinosa, Nuria; Roca-Oporto, Cristina; Herrero, Marta; Sotomayor, Cesar; López-Cortes, Luis F.
Afiliación
  • Mejías-Trueba M; Department of Pharmacy, University Hospital Virgen del Rocío, Seville, Spain.
  • Saborido-Alconchel A; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Serna-Gallego A; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Trujillo-Rodríguez M; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Muñoz-Muela E; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Llaves-Flores S; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Espinosa N; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Roca-Oporto C; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Herrero M; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • Sotomayor C; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
  • López-Cortes LF; Clinical Unit of Infectious Diseases, Clinical Microbiology and Parasitology. Institute of Biomedicine of Seville/Virgen del Rocio University Hospital/CSIC/University of Seville, Seville, Spain.
Front Immunol ; 15: 1447926, 2024.
Article en En | MEDLINE | ID: mdl-39267754
ABSTRACT
Despite effective antiretroviral therapy (ART), 15-30% of people with HIV experience poor CD4+ T-cell recovery, termed immunologic non-responders (INR). This study aims to evaluate whether pre-ART plasma levels of interleukin-6 (IL-6), interferon gamma-induced protein-10 (IP-10), macrophage inflammatory protein-1-ß (MIP-1ß), and/or pentraxin-3 (PTX-3) could predict subsequent immunologic recovery. Seventy-four participants were enrolled and classified as INR and immunologic responders (IR) based on CD4+/CD8+ ratio increase over 24 months after starting ART. The results showed no significant differences in cytokine levels between INR and IR. Therefore, IL-6, IP-10, MIP-1ß, and PTX-3 were unsuitable as predictive markers of poor immune recovery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Componente Amiloide P Sérico / Biomarcadores / Infecciones por VIH / Interleucina-6 / Quimiocina CCL4 / Quimiocina CXCL10 Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína C-Reactiva / Componente Amiloide P Sérico / Biomarcadores / Infecciones por VIH / Interleucina-6 / Quimiocina CCL4 / Quimiocina CXCL10 Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Front Immunol Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Suiza