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Neural basis of false recognition in Alzheimer's disease and dementia with lewy bodies.
Chadani, Yoshihiro; Fujito, Ryoko; Kimura, Naohiro; Kawai, Ryo; Kashibayashi, Tetsuo; Takahashi, Ryuichi; Kanemoto, Hideki; Ishii, Kazunari; Tagai, Kenji; Shinagawa, Shunichiro; Ikeda, Manabu; Kazui, Hiroaki.
Afiliación
  • Chadani Y; Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
  • Fujito R; Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
  • Kimura N; Graduate School of Integrated Arts and Sciences, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
  • Kawai R; Department of Rehabilitation, Atago Hospital Branch, 6012-1, Nagahama, Kochi City, Kochi, 781-0270, Japan.
  • Kashibayashi T; Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kohasu Oko-cho, Nankoku City, Kochi, 783-8505, Japan.
  • Takahashi R; Dementia-related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, 1-7-1, Kouto, Shingu-cho, Tatsuno City, Hyogo, 679-5165, Japan.
  • Kanemoto H; Dementia-related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, 1-7-1, Kouto, Shingu-cho, Tatsuno City, Hyogo, 679-5165, Japan.
  • Ishii K; Department of Psychiatry, Osaka University Graduate School of Medicine, D3, 2-2 Yamadaoka, Suita City, Osaka, 565-0871, Japan.
  • Tagai K; Health and Counseling Center, Osaka University, 1-17, Machikaneyama-cho, Toyonaka, Osaka, 560-0043, Japan.
  • Shinagawa S; Department of Radiology, Kindai University, Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama City, Osaka, 589-8511, Japan.
  • Ikeda M; Department of Psychiatry, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8471, Japan.
  • Kazui H; Department of Psychiatry, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8471, Japan.
Sci Rep ; 14(1): 21290, 2024 09 12.
Article en En | MEDLINE | ID: mdl-39266605
ABSTRACT
In Alzheimer's disease (AD), reports on the association between false recognition and brain structure have been inconsistent. In dementia with Lewy bodies (DLB), no such association has been reported. This study aimed to identify brain regions associated with false recognition in AD and DLB by analyzing regional gray matter volume (rGMV). We included 184 patients with AD and 60 patients with DLB. The number of false recognitions was assessed using the Alzheimer's Disease Assessment Scale' word recognition task. Brain regions associated with the number of false recognitions were examined by voxel-based morphometry analysis. The number of false recognitions significantly negatively correlated with rGMV in the bilateral hippocampus, left parahippocampal gyrus, bilateral amygdala, and bilateral entorhinal cortex in patients with AD (p < 0.05, family-wise error [FEW] corrected) and in the bilateral hippocampus, left parahippocampal gyrus, right inferior frontal gyrus, right middle frontal gyrus, right basal forebrain, right insula, left medial and lateral orbital gyri, and left fusiform in those with DLB (p < 0.05, FWE corrected). Bilateral hippocampus and left parahippocampal gyrus were associated with false recognition in both diseases. However, we found there were regions where the association between false recognition and rGMV differed from disease to disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Enfermedad por Cuerpos de Lewy / Enfermedad de Alzheimer Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Enfermedad por Cuerpos de Lewy / Enfermedad de Alzheimer Límite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido