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Phytochemical Diversity and Biological Effects of Juniperus thurifera L., Essential Oil : A Comparative Study using In Vitro and In Silico Methods.
Elhrech, Hamza; Aguerd, Oumayma; El Omari, Nasreddine; Benali, Taoufiq; Akhazzane, Mohamed; Alotaibi, Amal; Ullah, Riaz; Chamkhi, Imane; Bouyahya, Abdelhakim.
Afiliación
  • Elhrech H; Mohammed V University of Rabat, Biology, Rabat, Morocco, Rabat, MOROCCO.
  • Aguerd O; Mohammed V University of Rabat, Biology, Rabat, Morocco, Rabat, MOROCCO.
  • El Omari N; Universite Abdelmalek Essaadi, Biology, Tetouan Morocco, Tetouan, MOROCCO.
  • Benali T; Universite Cadi Ayyad, Biology, Safi, Morocco, Safi, MOROCCO.
  • Akhazzane M; Sidi Mohamed Ben Abdellah University, Chemistry, Route Immouzer, Fez, MOROCCO.
  • Alotaibi A; King Saud University, Biology, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia, Riyadh, SAUDI ARABIA.
  • Ullah R; King Saud University, Biology, College of Pharmacy King Saud University Riyadh Saudi Arabia, Riyadh, SAUDI ARABIA.
  • Chamkhi I; Mohammed V University of Rabat, Microbiology, Scientific Institute, Mohammed V University in Rabat, Morocco, Rabat, MOROCCO.
  • Bouyahya A; Mohammed V University of Rabat, Biology, Département de Biologie, 4 Avenue Ibn Batouta BP 1014 RP, RABAT, 10100, Rabat, MOROCCO.
Chem Biodivers ; : e202401654, 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39266453
ABSTRACT
This study aims to elucidate the phytochemical diversity and biological activities of J. thurifera essential oil (JTEO) through a comparative analysis of samples from two distinct regions Tensift-Al Haouz and Azilal, using both in vitro and in silico methods. Gas Chromatography-Mass Spectrometry (GC-MS) analysis revealed 21 components in the Tensift-Al Haouz JTEO (99.99% of the oil) and 23 components in the Azilal JTEO (99.58% of the oil), with oxygenated monoterpenes being the predominant compounds in both. The biological activities were assessed in vitro. Antioxidant properties, evaluated using DPPH, FRAP, and ABTS assays, showed significant activity in both oils. Antibacterial activity was tested against two strains of Gram-positive and two strains of Gram-negative bacteria, with both oils demonstrating notable bacterial growth inhibition. Enzymatic assays assessed the antidiabetic (α-amylase and α-glucosidase), dermo-protective (tyrosinase and elastase), and neuroprotective (AChE and BChE) activities. Both oils displayed substantial inhibitory effects across all tested activities, with variations attributed to their distinct chemical compositions. In silico analyses of six target enzymes confirmed significant binding affinities of the major compounds. Notably, 2,2'-Thiobis(6-tert-butyl-p-cresol) exhibited strong binding affinities with AChE, BChE, α-amylase, α-glucosidase, tyrosinase, and elastase, with binding energies ranging from -10.0 to -6.2 kcal/mol.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Biodivers Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2024 Tipo del documento: Article País de afiliación: Marruecos Pais de publicación: Suiza