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Unveiling the neurolipidome of obsessive-compulsive disorder: A scoping review navigating future diagnostic and therapeutic applications.
Fisher, Andre Lara; Arora, Kabir; Maehashi, Saki; Schweitzer, Daniel; Akefe, Isaac Oluwatobi.
Afiliación
  • Fisher AL; Medical School, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. Electronic address: a.l.fisher@uq.net.au.
  • Arora K; Medical School, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
  • Maehashi S; Medical School, Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.
  • Schweitzer D; Centre for Neurosciences, Mater Hospital, Brisbane, QLD, Australia.
  • Akefe IO; CDU Menzies School of Medicine, Charles Darwin University, Ellengowan Drive, Darwin, NT 0909, Australia. Electronic address: isaac.akefe@cdu.edu.au.
Neurosci Biobehav Rev ; 166: 105885, 2024 Nov.
Article en En | MEDLINE | ID: mdl-39265965
ABSTRACT
Obsessive-Compulsive Disorder (OCD) poses a multifaceted challenge in psychiatry, with various subtypes and severities greatly impacting well-being. Recent scientific attention has turned towards lipid metabolism, particularly the neurolipidome, in response to clinical demands for cost-effective diagnostics and therapies. This scoping review integrates recent animal, translational, and clinical studies to explore impaired neurolipid metabolism mechanisms in OCD's pathogenesis, aiming to enhance future diagnostics and therapeutics. Five key neurolipids - endocannabinoids, lipid peroxidation, phospholipids, cholesterol, and fatty acids - were identified as relevant. While the endocannabinoid system shows promise in animal models, its clinical application remains limited. Conversely, lipid peroxidation and disruptions in phospholipid metabolism exhibit significant impacts on OCD's pathophysiology based on robust clinical data. However, the role of cholesterol and fatty acids remains inconclusive. The review emphasises the importance of translational research in linking preclinical findings to real-world applications, highlighting the potential of the neurolipidome as a potential biomarker for OCD detection and monitoring. Further research is essential for advancing OCD understanding and treatment modalities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Obsesivo Compulsivo Límite: Animals / Humans Idioma: En Revista: Neurosci Biobehav Rev Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno Obsesivo Compulsivo Límite: Animals / Humans Idioma: En Revista: Neurosci Biobehav Rev Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos