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Pathologic Features of Malignancies Presenting as Asymmetry on Mammography.
Kahila, Mohamed M H; Chesebro, Allyson L; Giess, Catherine S; Rhei, Esther; Hong, Xuefei; Lester, Susan C.
Afiliación
  • Kahila MMH; Department of Pathology, Yale University, New Haven, Connecticut; Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Chesebro AL; Division of Breast Imaging, Department of Radiology, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Giess CS; Division of Breast Imaging, Department of Radiology, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  • Rhei E; Division of Breast Surgery, Department of Surgery, Brigham & Women's Hospital, Brigham and Women's Faulkner Hospital, and Harvard Medical School, Boston, Massachusetts.
  • Hong X; Department of Pathology, Brigham and Women's Faulkner Hospital and Harvard Medical School, Boston, Massachusetts.
  • Lester SC; Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: slester@bwh.harvard.edu.
Mod Pathol ; : 100612, 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39265951
ABSTRACT
The majority of breast cancers have a solid tumor growth pattern and are seen on mammography as dense masses with defined borders. Cancers detected as asymmetry are rare, and little has been published about their pathologic features. These cancers do not form discrete masses, and a border is not evident. This retrospective case series was undertaken to identify malignancies presenting as asymmetry, to describe their histologic and biologic features and to correlate these features with the mammographic appearance. During the 7.5 years of the study, 18,419 core needle biopsies (CNBs) were performed and 42 cases of malignancy presenting as asymmetry were diagnosed (0.2%). The majority were invasive carcinomas (30 or 71%), followed by ductal carcinoma in situ (9 or 21%) and lymphoma (3 or 7%). The invasive carcinomas could be divided into 3 groups very small unifocal (T1a) carcinomas, larger unifocal carcinomas, and cases with multiple foci of invasion. The latter group had a higher rate of lymph node metastases and more stage III cancers. The invasive carcinomas were predominantly of special histologic types and associated with a minimal stromal response. In contrast, the cases of DCIS tended to be of higher grade and elicited periductal fibrosis, which likely contributed to the increased density seen on mammography. Although most of the invasive carcinomas were of favorable biologic type (97%) and were stage I (67%), triple negative carcinomas, as well as stage III carcinomas, were also detected. When evaluating core needle biopsies performed for asymmetry, pathologists should be aware that these cancers can have a subtle infiltrative appearance with little or no desmoplastic response, mirroring their appearance by imaging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mod Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Mod Pathol Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos