Your browser doesn't support javascript.
loading
Ultra-radical surgery versus standard-radical surgery for the primary cytoreduction of advanced epithelial ovarian cancer; long-term tertiary center experiences.
Aksan, Alperen; Boran, Nurettin; Sinem Duru Coteli, Ayse; Ustun, Yaprak.
Afiliación
  • Aksan A; Department of Obstetrics and Gynecology, Obstetrics and Gynecology University of Health Sciences Turkey, Ankara Etlik Zubeyde Hanim Women's Health and Research Center Turkey, Ankara, Turkey. Electronic address: alprnaksn@gmail.com.
  • Boran N; Department of Gynecology Oncology, Obstetrics and Gynecology University of Health Sciences Turkey, Ankara Etlik Zubeyde Hanim Women's Health and Research Center Turkey, Ankara, Turkey.
  • Sinem Duru Coteli A; Department of Gynecology Oncology, Obstetrics and Gynecology University of Health Sciences Turkey, Ankara Etlik Zubeyde Hanim Women's Health and Research Center Turkey, Ankara, Turkey.
  • Ustun Y; Department of Obstetrics and Gynecology, Obstetrics and Gynecology University of Health Sciences Turkey, Ankara Etlik Zubeyde Hanim Women's Health and Research Center Turkey, Ankara, Turkey.
Eur J Obstet Gynecol Reprod Biol ; 302: 125-133, 2024 Sep 07.
Article en En | MEDLINE | ID: mdl-39265198
ABSTRACT

OBJECTIVE:

To compare overall survival (OS) and morbidity outcomes in patients with advanced epithelial ovarian/tubal/peritoneal cancer undergoing standard-radical (SR) and ultra-radical (UR) surgical procedures based on NICE classification. STUDY

DESIGN:

This retrospective study analyzed data from 282 patients with 2014 FIGO stage III-IV epithelial ovarian cancer operated on between January 2006 and January 2019. The study compared OS, progression-free survival (PFS), and morbidity between SR and UR surgeries. Parameters influencing OS, including preoperative, postoperative, and post-adjuvant chemotherapy CA-125 values, surgical procedures, post-surgical residual tumor, histopathological grade, and FIGO surgical stage, were assessed.

RESULTS:

Out of 282 patients, 256 met the inclusion criteria. SR surgery was performed in 48 %, and UR surgery in 52 %. The mean preoperative CA-125 value was 1200 ± 1914.83, decreasing to 240.32 ± 373.87 postoperatively. The mean follow-up period was 63.01 ± 47.56 months. UR surgery correlated with significantly higher postoperative complications (p < 0.001), histopathological grade (p = 0.023), FIGO stage (p < 0.001), three-year death rates, and overall mortality rates (p = 0.035). FIGO stage and total metastatic lymph nodes emerged as independent prognostic factors for overall and PFS.

CONCLUSION:

In the treatment of epithelial ovarian cancer, evaluating the extent of the tumor before the surgery and showing maximal effort to minimize the residual tumor volume instead of applying UR procedures as the first choice seems to be the most important factor that can affect survival.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Obstet Gynecol Reprod Biol Año: 2024 Tipo del documento: Article Pais de publicación: Irlanda