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Unraveling the phenotypic states of human innate-like T cells: Comparative insights with conventional T cells and mouse models.
Loh, Liyen; Carcy, Salomé; Krovi, Harsha S; Domenico, Joanne; Spengler, Andrea; Lin, Yong; Torres, Joshua; Prabakar, Rishvanth K; Palmer, William; Norman, Paul J; Stone, Matthew; Brunetti, Tonya; Meyer, Hannah V; Gapin, Laurent.
Afiliación
  • Loh L; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Carcy S; School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Krovi HS; Brigham and Women's Hospital, Boston, MA, USA.
  • Domenico J; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Spengler A; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Lin Y; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Torres J; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Prabakar RK; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • Palmer W; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Norman PJ; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Stone M; Children's Hospital Colorado, Aurora, CO, USA.
  • Brunetti T; University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Meyer HV; Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. Electronic address: hmeyer@cshl.edu.
  • Gapin L; University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: laurent.gapin@cuanschutz.edu.
Cell Rep ; 43(9): 114705, 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39264810
ABSTRACT
The "innate-like" T cell compartment, known as Tinn, represents a diverse group of T cells that straddle the boundary between innate and adaptive immunity. We explore the transcriptional landscape of Tinn compared to conventional T cells (Tconv) in the human thymus and blood using single-cell RNA sequencing (scRNA-seq) and flow cytometry. In human blood, the majority of Tinn cells share an effector program driven by specific transcription factors, distinct from those governing Tconv cells. Conversely, only a fraction of thymic Tinn cells displays an effector phenotype, while others share transcriptional features with developing Tconv cells, indicating potential divergent developmental pathways. Unlike the mouse, human Tinn cells do not differentiate into multiple effector subsets but develop a mixed type 1/type 17 effector potential. Cross-species analysis uncovers species-specific distinctions, including the absence of type 2 Tinn cells in humans, which implies distinct immune regulatory mechanisms across species.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cell Rep Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos