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A six-year study in a real-world population reveals an increased incidence of dyslipidemia during COVID-19.
Trimarco, Valentina; Izzo, Raffaele; Jankauskas, Stanislovas S; Fordellone, Mario; Signoriello, Giuseppe; Manzi, Maria Virginia; Lembo, Maria; Gallo, Paola; Esposito, Giovanni; Piccinocchi, Roberto; Rozza, Francesco; Morisco, Carmine; Mone, Pasquale; Piccinocchi, Gaetano; Varzideh, Fahimeh; Trimarco, Bruno; Santulli, Gaetano.
Afiliación
  • Trimarco V; Department of Neuroscience, Reproductive Sciences, and Dentistry and.
  • Izzo R; Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
  • Jankauskas SS; Department of Molecular Pharmacology, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York, USA.
  • Fordellone M; Department of Mental, Physical Health and Preventive Medicine and.
  • Signoriello G; Department of Experimental Medicine, University of Campania "Luigi Vanvitelli," Naples, Italy.
  • Manzi MV; Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
  • Lembo M; Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
  • Gallo P; Department of Neuroscience, Reproductive Sciences, and Dentistry and.
  • Esposito G; Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
  • Piccinocchi R; "Luigi Vanvitelli" Hospital, Naples, Italy.
  • Rozza F; Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
  • Morisco C; Department of Advanced Biomedical Sciences, "Federico II" University, Naples, Italy.
  • Mone P; Italian Society for Cardiovascular Prevention (SIPREC), Rome, Italy.
  • Piccinocchi G; International Translational Research and Medical Education (ITME), Academic Research Unit, Naples, Italy.
  • Varzideh F; Department of Molecular Pharmacology, Fleischer Institute for Diabetes and Metabolism (FIDAM), Einstein Institute for Aging Research, Albert Einstein College of Medicine, New York, New York, USA.
  • Trimarco B; Department of Medicine and Health Sciences "Vincenzo Tiberio," Molise University, Campobasso, Italy.
  • Santulli G; Casa di Cura Montevergine, Mercogliano, Avellino, Italy.
J Clin Invest ; 134(21)2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39264723
ABSTRACT
BACKGROUNDRecent studies conducted in individuals who survived COVID-19 suggest that SARS-CoV-2 infection is associated with an increased risk of dyslipidemia. However, it remains unclear whether this augmented risk is confirmed in the general population and how this phenomenon is affecting the overall burden of cardiometabolic diseases.METHODSTo address these aspects, we conducted a 6-year longitudinal study to examine the broader effects of COVID-19 on dyslipidemia incidence in a real-world population (228,266 individuals) residing in Naples in southern Italy. The pre-COVID-19 and COVID-19 groups were balanced for demographic and clinical factors using propensity score matching.RESULTSOur analysis spans a period of 3 years during the COVID-19 pandemic (2020-2022), comparing dyslipidemia incidence with pre-pandemic data (2017-2019), with a follow-up of at least 1,095 days corresponding to 21,349,215 person-years. During the COVID-19 period, we detected an increased risk of developing any dyslipidemia when compared with the pre-COVID-19 triennium (OR = 1.29; 95% CI, 1.19-1.39). Importantly, these estimates were adjusted for comorbidities by a multivariate analysis.CONCLUSIONSTaken together, our data reveal a notable rise in dyslipidemia incidence during the COVID-19 pandemic, suggesting the utility of establishing specialized clinical monitoring protocols for patients who survive COVID-19 to mitigate the risk of developing dyslipidemia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dislipidemias / SARS-CoV-2 / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Clin Invest Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dislipidemias / SARS-CoV-2 / COVID-19 Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: J Clin Invest Año: 2024 Tipo del documento: Article Pais de publicación: Estados Unidos