Organocatalytic Deoxygenative [3+2] Cycloaddition of <i>N</i>-Hydroxyamides with Alkynes to Access Isoxazoles.

Wang, Haixiang; Sun, Yan; Liu, Wentong; Huang, Liliang; Feng, Huangdi

Organocatalytic Deoxygenative [3+2] Cycloaddition of N-Hydroxyamides with Alkynes to Access Isoxazoles.

Wang, Haixiang; Sun, Yan; Liu, Wentong; Huang, Liliang; Feng, Huangdi.

Afiliación

Wang H; College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Sun Y; College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Liu W; College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Huang L; College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.
Feng H; College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China.

Org Lett ; 2024 Sep 12.

Article en En | MEDLINE | ID: mdl-39264213

ABSTRACT

ABSTRACT

Although the transition-metal-catalyzed [3+2] cycloadditions to access isoxazoles have been described well, organocatalytic methods remain underdeveloped. Herein, we report the use of an organophosphine catalyst for the preparation of a series of isoxazoles with exceptional regioselectivity via the [3+2] cycloaddition of N-hydroxyamides and alkynes. The scope of this organocatalytic transformation is broad, tolerating numerous functional groups and proceeding uniformly in an environmentally friendly, simple, and efficient manner.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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