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Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns.
Silva Barbosa, Joycilene da; Meneses, Gdayllon Cavalcante; Castelo, Luan Rebouças; da Silva Júnior, Geraldo Bezerra; Costa Martins, Alice Maria; Francesco Daher, Elizabeth De; Sampaio, Tiago Lima; Oliveira Gomes, Amanda de; Carvalho Dantas, Suzzy Maria; Silva Rebouças, Arthur da; de Lima, Paula Roberta; Lopes, Nicole Coelho; da Silva, Mateus Edson; Rodrigues da Costa, Mac Dionys; Reis Jereissati, Ana Amelia; Ramos, Victoria Queiroz; Gonçalves Machado, Rosângela Pinheiro; Gonçalves Lemes, Romélia Pinheiro.
Afiliación
  • Silva Barbosa JD; Postgraduate Program in Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Meneses GC; Postgraduate Program in Medical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Castelo LR; Postgraduate Program in Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • da Silva Júnior GB; Public Health & Medical Sciences Graduate Programs, School of Medicine, University of Fortaleza, Fortaleza, Ceará, Brazil.
  • Costa Martins AM; Department of Clinical & Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Francesco Daher E; Postgraduate Program in Medical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Sampaio TL; Department of Clinical & Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Oliveira Gomes A; Postgraduate Program in Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Carvalho Dantas SM; Postgraduate Program in Pathology, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Silva Rebouças AD; Postgraduate Program in Pharmaceutical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • de Lima PR; Postgraduate Program in Medical Sciences, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Lopes NC; Department of Clinical & Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • da Silva ME; Department of Clinical & Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Rodrigues da Costa MD; Department of Clinical & Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
  • Reis Jereissati AA; Postgraduate Program in Collective Health, University of Fortaleza, Fortaleza, Ceará, Brazil.
  • Ramos VQ; School of Medicine, University of Fortaleza, Fortaleza, Ceará, Brazil.
  • Gonçalves Machado RP; Health Sciences Center, School of Medicine, University of Fortaleza, Ceará, Brazil.
  • Gonçalves Lemes RP; Department of Clinical & Toxicological Analysis, School of Pharmacy, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Biomark Med ; 18(15-16): 649-658, 2024 Aug 17.
Article en En | MEDLINE | ID: mdl-39263780
ABSTRACT

Aim:

To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay.

Methods:

Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1.

Results:

Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio 1.052; 95% CI 1.012-1.093; p = 0.01).

Conclusion:

uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Biomarcadores / Sepsis / Cistatina C / Lipocalina 2 / Tiempo de Internación Límite: Female / Humans / Male / Newborn Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recien Nacido Prematuro / Biomarcadores / Sepsis / Cistatina C / Lipocalina 2 / Tiempo de Internación Límite: Female / Humans / Male / Newborn Idioma: En Revista: Biomark Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido