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Understanding the role of miRNAs in cervical cancer pathogenesis and therapeutic responses.
Chauhan, Prashant; Pramodh, Sreepoorna; Hussain, Arif; Elsori, Deena; Lakhanpal, Sorabh; Kumar, Rahul; Alsaweed, Mohammed; Iqbal, Danish; Pandey, Pratibha; Al Othaim, Ayoub; Khan, Fahad.
Afiliación
  • Chauhan P; MPA Research, Greater Noida, Uttar Pradesh, India.
  • Pramodh S; Department of Biomedical Sciences, University of Birmingham Dubai, Dubai, United Arab Emirates.
  • Hussain A; School of Life Sciences, Manipal Academy of Higher Education, Dubai, United Arab Emirates.
  • Elsori D; Faculty of Resilience, Rabdan Academy, Abu Dhabi, United Arab Emirates.
  • Lakhanpal S; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
  • Kumar R; Chitkara Centre for Research and Development, Chitkara University, Baddi, Himachal Pradesh, India.
  • Alsaweed M; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al-Majmaah, Saudi Arabia.
  • Iqbal D; Department of Health Information Management, College of Applied Medical Sciences, Buraydah Private Colleges, Buraydah, Saudi Arabia.
  • Pandey P; Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, India.
  • Al Othaim A; Centre for Research Impact and Outcome, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
  • Khan F; Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al-Majmaah, Saudi Arabia.
Front Cell Dev Biol ; 12: 1397945, 2024.
Article en En | MEDLINE | ID: mdl-39263322
ABSTRACT
Cervical cancer (CC) is the most common cancer in women and poses a serious threat to health. Despite familiarity with the factors affecting its etiology, initiation, progression, treatment strategies, and even resistance to therapy, it is considered a significant problem for women. However, several factors have greatly affected the previous aspects of CC progression and treatment in recent decades. miRNAs are short non-coding RNA sequences that regulate gene expression by inhibiting translation of the target mRNA. miRNAs play a crucial role in CC pathogenesis by promoting cancer stem cell (CSC) proliferation, postponing apoptosis, continuing the cell cycle, and promoting invasion, angiogenesis, and metastasis. Similarly, miRNAs influence important CC-related molecular pathways, such as the PI3K/AKT/mTOR signaling pathway, Wnt/ß-catenin system, JAK/STAT signaling pathway, and MAPK signaling pathway. Moreover, miRNAs affect the response of CC patients to chemotherapy and radiotherapy. Consequently, this review aims to provide an acquainted summary of onco miRNAs and tumor suppressor (TS) miRNAs and their potential role in CC pathogenesis and therapy responses by focusing on the molecular pathways that drive them.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2024 Tipo del documento: Article País de afiliación: India Pais de publicación: Suiza