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L-carnitine combined with traditional Chinese medicine for male infertility: A systematic review and meta-analysis.
Yang, Yang; Xue, Xinyu; Zhou, Jun; Qiu, Zerui; Wang, Biao; Yin, Ziwei; Ou, Guangyang; Zhou, Qing.
Afiliación
  • Yang Y; The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
  • Xue X; Hunan University of Chinese Medicine, Changsha, China.
  • Zhou J; The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
  • Qiu Z; The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
  • Wang B; The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
  • Yin Z; The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
  • Ou G; The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China.
  • Zhou Q; The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Heliyon ; 10(17): e36680, 2024 Sep 15.
Article en En | MEDLINE | ID: mdl-39263096
ABSTRACT

Background:

Fertility rates are declining globally, and male infertility is increasingly recognized as a significant challenge. This study aims to present the latest findings on the effectiveness and safety of combining traditional Chinese medicine (TCM) with L-carnitine (LC) for treating male infertility.

Methods:

We searched 8 databases. Randomized controlled trials of TCM combined with LC therapy versus LC alone in the treatment of male infertility. The outcome included pregnancy rate, sperm motility, concentration, volume, viability and liquefaction time. Subgroup analyses were also performed according to type of TCM, type of dosage form, and different TCM treatments, and the source of the high heterogeneity was explored. The study is registered on PROSPERO (CRD42023421497).

Results:

1129 subjects from 12 of the 1833 eligible studies fulfilled the criteria. Compared with LC treatment alone, the combination of TCM and LC significantly improved pregnancy rate [RR = 1.65, 95 % CI (1.37-2.00)], grade (a+b) sperm motility [SMD = 1.56, 95 % CI (1.12, 2.01)], grade (a) sperm motility [SMD = 1.04, 95 % CI (0.69, 1.38)], sperm concentration [SMD = 1.39, 95 % CI (0.91, 1.86)], and sperm viability [SMD = 1.72, 95 % CI (0.83, 2.60)]. Subgroup analyses indicated that Compound Xuanju Capsule and Yougui Capsule demonstrated better efficacy. And the decoction and not-decoction each had their own advantages.

Conclusions:

The combination of TCM with LC can have a dual effect increasing pregnancy rates and sperm quality. Therefore, this combination is a recommended therapeutic strategy and a more appropriate type of TCM can be selected according to the patient's own characteristics.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Heliyon Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido