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Development and characterization of polysiloxane-based gel loaded with phytoingredients encapsulated in phytosomes for scar management.
Naseriyeh, Tahereh; Kahrizi, Danial; Arkan, Elham; Moradi, Sajad; Kahrizi, Farzad.
Afiliación
  • Naseriyeh T; Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University Kermanshah, Iran. taherehnaseriyeh@gmail.com.
  • Kahrizi D; Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University Kermanshah, Iran. dkahrizi@modares.ac.ir.
  • Arkan E; Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. e.arkan@kums.ac.ir.
  • Moradi S; Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. sajadmoradi28@gmail.com.
  • Kahrizi F; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damghan Branch, Islamic Azad University, Damghan, Iran. f.kahrizi161@gmail.com.
Cell Mol Biol (Noisy-le-grand) ; 70(8): 235-243, 2024 Sep 08.
Article en En | MEDLINE | ID: mdl-39262266
ABSTRACT
Recent research has emphasized the development of efficient drug delivery systems to facilitate the delivery of biological compounds such as polyphenols via skin absorption. Phytozomes have been employed as carriers of plant compounds in this context Hydrogen bonding between plant polyphenols and the phospholipid phosphate group enables efficient encapsulation of potent compounds for enhanced drug delivery systems. Additionally, the strong affinity of phytosomes for the skin's phospholipids enhances skin absorption. In this study, phytosomes were initially formulated using the thin-layer hydration method After optimizing the synthetic parameters, phytosomes were loaded with Resveratrol and Quercetin for enhanced delivery and skin absorption potential to assess the characteristics of the synthesized phytosomes, tests were conducted to determine particle distribution and size, zeta potential, and examine the microstructure morphology using a scanning electron microscope (SEM). Furthermore, a siloxane gel base was formulated in this study, and the stability of the physicochemical and biological properties of the final prepared nanoformulation was investigated. The results of this study indicated that the formulated phytosomes exhibit optimal characteristics for facilitating high skin penetration of resveratrol and quercetin. A high skin absorption was observed after 60 days of synthesis. Additionally, the base of the siloxane gel can play a significant role in preventing the formation of scars by reducing the passage of water vapor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quercetina / Siloxanos / Cicatriz / Resveratrol / Geles Límite: Animals Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quercetina / Siloxanos / Cicatriz / Resveratrol / Geles Límite: Animals Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Francia