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The molecular mechanism of ferroptosis-induced spontaneous abortion based on bioinformatics approach.
Zhang, Feng; Zhang, Bing; Yin, Tingting; Qian, Fangbo; Lu, Bin; Zhu, Weipei.
Afiliación
  • Zhang F; Department of Gynaecology and Obstetric, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, China. zhangfeng2002@foxmail.com.
  • Zhang B; Wuxi Maternal and Child Health Care Hospital, The Affiliated Maternity Hospital of Jiangnan University, Wuxi, Jiangsu, 214002, China. yanghezhangbing@163.com.
  • Yin T; Wuxi Maternal and Child Health Care Hospital, The Affiliated Maternity Hospital of Jiangnan University, Wuxi, Jiangsu, 214002, China. yintingting86@126.com.
  • Qian F; Wuxi Maternal and Child Health Care Hospital, The Affiliated Maternity Hospital of Jiangnan University, Wuxi, Jiangsu, 214002, China. qfb20962096@163.com.
  • Lu B; Department of Gynaecology and Obstetric, The First People's Hospital of Wuhu Wuhu, Anhui, 241000, China. perk34388569@163.com.
  • Zhu W; Department of Gynaecology and Obstetric, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215004, China. zwp333xx@126.com.
Cell Mol Biol (Noisy-le-grand) ; 70(8): 129-136, 2024 Sep 08.
Article en En | MEDLINE | ID: mdl-39262253
ABSTRACT
Spontaneous abortion (SA) is a prevalent placental dysfunction, and ferroptosis may play a crucial role in placental dysfunction and the development of SA. In this study, we employed data mining and analysis techniques to investigate the biological mechanism of SA induced by ferroptosis, resulting in the identification of a total of 79 ferroptosis-related genes in SA were identified. Among them, 3 co-expression modules of ferroptosis risk genes, ten significant functions and six biologically significant pathways were obtained 61 pairs of differentially expressed miRNA-ferroptosis factor relationships were identified, and WIPI1 and GSN were expressed at significantly higher levels in SA. This is extremely helpful for future research on SA.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Espontáneo / Biología Computacional / MicroARNs / Ferroptosis Límite: Female / Humans / Pregnancy Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aborto Espontáneo / Biología Computacional / MicroARNs / Ferroptosis Límite: Female / Humans / Pregnancy Idioma: En Revista: Cell Mol Biol (Noisy-le-grand) Asunto de la revista: BIOLOGIA MOLECULAR Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia