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Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles.
Drouard, Gabin; Wang, Zhiyang; Heikkinen, Aino; Foraster, Maria; Julvez, Jordi; Kanninen, Katja M; van Kamp, Irene; Pirinen, Matti; Ollikainen, Miina; Kaprio, Jaakko.
Afiliación
  • Drouard G; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland. gabin.drouard@helsinki.fi.
  • Wang Z; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Heikkinen A; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Foraster M; PHAGEX Research Group, Blanquerna School of Health Science, Universitat Ramon Llull (URL), Barcelona, Spain.
  • Julvez J; Clinical and Epidemiological Neuroscience (NeuroÈpia), Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.
  • Kanninen KM; ISGlobal, Parc de Recerca Biomèdica de Barcelona (PRBB), Barcelona, Spain.
  • van Kamp I; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
  • Pirinen M; Centre for Sustainability, Environment and Health, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
  • Ollikainen M; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.
  • Kaprio J; Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sci Rep ; 14(1): 21261, 2024 09 11.
Article en En | MEDLINE | ID: mdl-39261679
ABSTRACT
Whether differences in lifestyle between co-twins are reflected in differences in their internal or external exposome profiles remains largely underexplored. We therefore investigated whether within-pair differences in lifestyle were associated with within-pair differences in exposome profiles across four domains the external exposome, proteome, metabolome and epigenetic age acceleration (EAA). For each domain, we assessed the similarity of co-twin profiles using Gaussian similarities in up to 257 young adult same-sex twin pairs (54% monozygotic). We additionally tested whether similarity in one domain translated into greater similarity in another. Results suggest that a lower degree of similarity in co-twins' exposome profiles was associated with greater differences in their behavior and substance use. The strongest association was identified between excessive drinking behavior and the external exposome. Overall, our study demonstrates how social behavior and especially substance use are connected to the internal and external exposomes, while controlling for familial confounders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exposoma / Estilo de Vida Límite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Exposoma / Estilo de Vida Límite: Adult / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2024 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Reino Unido