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Enhanced production of health-promoting phenolic compounds using a novel endophytic fungus Talaromyces neorugulosus R-209 isolated from pigeon pea in a natural habitat by l-phenylalanine feeding.
Fu, Jin-Xian; Jiao, Jiao; Gai, Qing-Yan; Fu, Yu-Jie; Gao, Jie; Zhang, Zi-Yi; Wang, Yuan; Wang, Xiao-Qing.
Afiliación
  • Fu JX; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China.
  • Jiao J; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China.
  • Gai QY; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, PR China.
  • Fu YJ; Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Northeast Forestry University, Harbin, 150040, PR China.
  • Gao J; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China. jj_nefu@163.com.
  • Zhang ZY; Engineering Research Center of Forest Bio-Preparation, Ministry of Education, Northeast Forestry University, Harbin, 150040, PR China. jj_nefu@163.com.
  • Wang Y; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, 150040, PR China. jj_nefu@163.com.
  • Wang XQ; Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-based Active Substances, Northeast Forestry University, Harbin, 150040, PR China. jj_nefu@163.com.
World J Microbiol Biotechnol ; 40(10): 317, 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39261398
ABSTRACT
In this study, nine endophytic fungi capable of producing multiple phenolic compounds were screened and identified from 152 fungi isolated from pigeon pea in a natural habitat (Honghe, Yunnan Province, China). Talaromyces neorugulosus R-209 exhibited the highest potential for phenolic compound production. L-phenylalanine feeding was used to enhance phenolic compound production in T. neorugulosus R-209 cultures. Under the optimal feeding conditions (l-phenylalanine dose of 0.16 g/L and feeding phase of 6 days), the yields of genistein, apigenin, biochanin A, and cajaninstilbene acid increased by 15.59-fold, 7.20-fold, 25.93-fold, and 10.30-fold over control, respectively. T. neorugulosus R-209 fed with l-phenylalanine was found to be stable in the production of phenolic compounds during ten successive subcultures. Moreover, bioactivities of extracts of T. neorugulosus R-209 cultures were significantly increased by l-phenylalanine feeding. Overall, l-phenylalanine feeding strategy made T. neorugulosus R-209 more attractive as a promising alternative source for the production of health-beneficial phenolic compounds in the nutraceutical/medicinal industries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Fenilalanina / Talaromyces / Cajanus / Endófitos País/Región como asunto: Asia Idioma: En Revista: World J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Fenilalanina / Talaromyces / Cajanus / Endófitos País/Región como asunto: Asia Idioma: En Revista: World J Microbiol Biotechnol Año: 2024 Tipo del documento: Article Pais de publicación: Alemania