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Structural connectivity modifications following deep brain stimulation of the subcallosal cingulate and nucleus accumbens in severe anorexia nervosa.
Abellaneda-Pérez, Kilian; Delgado-Martínez, Ignacio; Salgado, Purificación; Ginés, José María; Guardiola, Rocío; Vaqué-Alcázar, Lídia; Roca-Ventura, Alba; Molist-Puigdomènech, Roger; Manero, Rosa María; Viles-Garcia, Marc; Medrano-Martorell, Santiago; Bartrés-Faz, David; Pascual-Leone, Alvaro; Pérez-Solà, Víctor; Villalba-Martínez, Gloria.
Afiliación
  • Abellaneda-Pérez K; Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
  • Delgado-Martínez I; Universitat Autònoma de Barcelona, Bellaterra, Cerdanyola del Vallès, Spain.
  • Salgado P; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.
  • Ginés JM; Human Anatomy and Embryology Unit, Department of Morphological Sciences, Faculty of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain.
  • Guardiola R; Institut de Neuropsiquiatria i Addiccions (INAD), Hospital del Mar, Barcelona, Spain.
  • Vaqué-Alcázar L; Institut de Neuropsiquiatria i Addiccions (INAD), Hospital del Mar, Barcelona, Spain.
  • Roca-Ventura A; Institut de Neuropsiquiatria i Addiccions (INAD), Hospital del Mar, Barcelona, Spain.
  • Molist-Puigdomènech R; Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
  • Manero RM; Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Viles-Garcia M; Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, Badalona, Barcelona, Spain.
  • Medrano-Martorell S; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.
  • Bartrés-Faz D; Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
  • Pascual-Leone A; Departament de Psicologia, Universitat de Lleida, Lleida, Spain.
  • Pérez-Solà V; Department of Neurology, Hospital del Mar, Barcelona, Spain.
  • Villalba-Martínez G; Department of Radiology, Hospital del Mar, Barcelona, Spain.
Acta Neurochir (Wien) ; 166(1): 364, 2024 Sep 12.
Article en En | MEDLINE | ID: mdl-39261306
ABSTRACT

PURPOSE:

Anorexia nervosa (AN) is a mental health disorder characterized by significant weight loss and associated medical and psychological comorbidities. Conventional treatments for severe AN have shown limited effectiveness, leading to the exploration of novel interventional strategies, including deep brain stimulation (DBS). However, the neural mechanisms driving DBS interventions, particularly in psychiatric conditions, remain uncertain. This study aims to address this knowledge gap by examining changes in structural connectivity in patients with severe AN before and after DBS.

METHODS:

Sixteen participants, including eight patients with AN and eight controls, underwent baseline T1-weigthed and diffusion tensor imaging (DTI) acquisitions. Patients received DBS targeting either the subcallosal cingulate (DBS-SCC, N = 4) or the nucleus accumbens (DBS-NAcc, N = 4) based on psychiatric comorbidities and AN subtype. Post-DBS neuroimaging evaluation was conducted in four patients. Data analyses were performed to compare structural connectivity between patients and controls and to assess connectivity changes after DBS intervention.

RESULTS:

Baseline findings revealed that structural connectivity is significantly reduced in patients with AN compared to controls, mainly regarding callosal and subcallosal white matter (WM) tracts. Furthermore, pre- vs. post-DBS analyses in AN identified a specific increase after the intervention in two WM tracts the anterior thalamic radiation and the superior longitudinal fasciculus-parietal bundle.

CONCLUSIONS:

This study supports that structural connectivity is highly compromised in severe AN. Moreover, this investigation preliminarily reveals that after DBS of the SCC and NAcc in severe AN, there are WM modifications. These microstructural plasticity adaptations may signify a mechanistic underpinning of DBS in this psychiatric disorder.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Estimulación Encefálica Profunda / Imagen de Difusión Tensora / Giro del Cíngulo / Núcleo Accumbens Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Acta Neurochir (Wien) Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Austria
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anorexia Nerviosa / Estimulación Encefálica Profunda / Imagen de Difusión Tensora / Giro del Cíngulo / Núcleo Accumbens Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Acta Neurochir (Wien) Año: 2024 Tipo del documento: Article País de afiliación: España Pais de publicación: Austria