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Hydrogen-bonded organic frameworks as stationary phase for open-tubular capillary electrochromatography.
Ning, Weijie; Xiang, Yuhong; Zhang, Lu; Ye, Nengsheng.
Afiliación
  • Ning W; Department of Chemistry, Capital Normal University, Beijing, 100048, China.
  • Xiang Y; Department of Chemistry, Capital Normal University, Beijing, 100048, China.
  • Zhang L; Department of Chemistry, Capital Normal University, Beijing, 100048, China. Electronic address: zhangl@cnu.edu.cn.
  • Ye N; Department of Chemistry, Capital Normal University, Beijing, 100048, China. Electronic address: yensh@cnu.edu.cn.
Anal Chim Acta ; 1326: 343148, 2024 Oct 16.
Article en En | MEDLINE | ID: mdl-39260915
ABSTRACT

BACKGROUND:

Capillary electrochromatography (CEC) stationary phases have always been the focus of attention. The selection of excellent stationary phases are the key to realize separate of different compounds. Hydrogen-bonded organic frameworks (HOFs) are porous materials connected by hydrogen bonds between molecules, which have the advantages of renewable, high specific surface area and mild synthesis conditions. At present, HOFs are used in gas adsorption and storage, catalysis and drug delivery. Because of its unique advantages, HOFs have a bright future as CEC stationary phases.

RESULTS:

Using melamine (MA) and 1,3,6,8-tetra (4-carboxylphenyl)pyrene (H4TBAPy) as reaction monomers, a HOFs named MA/PFC-1 was synthesized by solvent evaporation at room temperature. The inner wall of the capillary column was coated with MA/PFC-1 by chemical bonding. Sulfonamides were used as the target analytes. The effects of pH, phosphate buffer solution concentration, organic additive content and applied voltage on sulfonamides separation were investigated. The MA/PFC-1-coated capillary column had good resolution (>1.5) and reproducibility. The intra-day, inter-day, column-to-column, and inter-batch precision of the retention times were 0.03%-0.09%, 0.04%-0.09%, 0.03%-0.14% and 0.06%-0.09%, respectively. The intra-day, inter-day, column-to-column, and inter-batch precision of the peak areas were 0.11%-0.25%, 0.13%-0.20%, 0.12%-0.15% and 0.08%-0.15%, respectively. The MA/PFC-1-coated capillary column was run 150 consecutive times, and the results showed no noticeable change, which proved that this method had good stability.

SIGNIFICANCE:

This work applied HOFs to CEC. The results show the that MA/PFC-1-coated capillary column has good separation performance. The MA/PFC-1-coated capillary column has been successfully applied to the determination of sulfamethoxazole in tablets, which has practical application value. To open up the application of HOFs in CEC and provide a new idea for developing new CEC stationary phases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Anal Chim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Anal Chim Acta Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos