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Pathophysiological characteristics of subjects with intermediate hyperglycemia and type 2 diabetes identified by 1-hour plasma glucose during an oral glucose tolerance test.
Cefalo, Chiara M A; Riccio, Alessia; Fiorentino, Teresa Vanessa; Succurro, Elena; Mannino, Gaia Chiara; Perticone, Maria; Sciacqua, Angela; Andreozzi, Francesco; Sesti, Giorgio.
Afiliación
  • Cefalo CMA; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, 00189 Rome, Italy.
  • Riccio A; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, 00189 Rome, Italy.
  • Fiorentino TV; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. Electronic address: vanessa.fiorentino@unicz.it.
  • Succurro E; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  • Mannino GC; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  • Perticone M; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  • Sciacqua A; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  • Andreozzi F; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy.
  • Sesti G; Department of Clinical and Molecular Medicine, University of Rome-Sapienza, 00189 Rome, Italy.
Diabetes Res Clin Pract ; 217: 111856, 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39260622
ABSTRACT

AIMS:

The International Diabetes Federation (IDF) has recently recommended determination of 1-hour plasma glucose (1-hPG) during an oral glucose tolerance test (OGTT) to diagnose intermediate hyperglycemia (IH) and type 2 diabetes (T2DM). Herein, we investigated the cardiometabolic characteristics of individuals with IH and T2DM according to IDF criteria.

METHODS:

We studied 3086 individuals stratified on the basis of fasting, 1-hPG and 2-hPG in four groups 1) normal glucose tolerance (NGT), 2) isolated impaired fasting glucose (iIFG,), 3) IH (fasting glucose < 126 mg/dL, 1-hPG 155-208 mg/dL, and/or 2-hPG 140-199 mg/dL, and 4) newly diagnosed T2DM (fasting glucose, 1-hPG and/or 2-hPG≥126 mg/dL, 209 mg/dL and 200 mg/dL, respectively).

RESULTS:

Individuals with IH and T2DM exhibited higher adiposity, blood pressure, uric acid, a worse lipid and inflammatory profile and a progressive reduction in Matsuda index of insulin sensitivity, insulinogenic index, and disposition index as compared to the NGT group. Moreover, individuals with IH and T2DM exhibited lower Matsuda, insulinogenic, and disposition indexes as compared to the iIFG group.

CONCLUSIONS:

1-h PG-based criteria for diagnosis of IH and diabetes identify individuals having an unfavorable cardiometabolic risk profile with a progressive reduction in insulin sensitivity associated with impaired ß cell function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Diabetes Res Clin Pract Asunto de la revista: ENDOCRINOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Irlanda