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Comprehensive modulatory effects of whole grain consumption on immune-mediated inflammation in middle-aged and elderly community residents: A real-world randomized controlled trial.
Li, Cheng; Li, Yaru; Wang, Nan; Ge, Zhiwen; Wang, Jia; Ding, Bingjie; Bi, Yanxia; Wang, Yuxia; Wang, Yisi; Peng, Zebin; Yang, Xinli; Wang, Congcong; Hong, Zhongxin.
Afiliación
  • Li C; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Li Y; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang N; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Ge Z; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang J; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Ding B; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Bi Y; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang Y; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang Y; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Peng Z; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Yang X; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Wang C; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Hong Z; Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China. Electronic address: hongzhongxin@vip.sina.com.
Redox Biol ; 76: 103337, 2024 Oct.
Article en En | MEDLINE | ID: mdl-39260062
ABSTRACT
BACKGROUND AND

AIMS:

Whole grain consumption is widely recognized as a vital component of a balanced diet. Dietary fiber has been well-documented to play a crucial role in these health benefits attributed to whole grain intake. However, population-based evidence directly linking whole grain consumption to anti-inflammatory effects, especially in the context of immune-mediated inflammation, remains limited. We hypothesized that whole grain consumption promotes health by modulating immune-mediated inflammation. METHODS AND

RESULTS:

This study was designed as a real-world, population-based randomized controlled trial. We compared the effects of whole grain versus refined grain consumption on immune-mediated inflammation through staple food substitution, while participants maintained their usual dietary practices. The results demonstrated that whole grain consumption significantly reduced circulating levels of pro-inflammatory cytokines IL-22 and IL-23 compared to refined grain consumption. These reductions were associated with optimized short-chain fatty acid profiles and changes in CD4+ T cell subset distributions.

CONCLUSIONS:

The findings suggest that the anti-inflammatory effects of whole grain consumption in middle-aged and elderly populations are mediated by targeting specific CD4+ T cell subsets, in addition to modulating both upstream short-chain fatty acid composition and downstream expression of the pro-inflammatory cytokines IL-22 and IL-23.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Granos Enteros / Inflamación Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Redox Biol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Granos Enteros / Inflamación Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Redox Biol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos