A new player in the biogenesis of lysosome-related organelles.

Shi, Anbing

Shi, Anbing.

Afiliación

Shi A; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Disease, Huazhong University of Science and Technology, Wuhan, China.

J Cell Biol ; 223(10)2024 Oct 07.

Article en En | MEDLINE | ID: mdl-39259305

ABSTRACT

ABSTRACT

How are Rab GTPases regulated during lysosome-related organelle (LRO) biogenesis? Li et al. (https//doi.org/10.1083/jcb.202402016) identify LYSMD proteins as crucial activators of Rab32-family GTPases in LRO development, shedding light on the previously ambiguous mechanisms governing Rab functionality in this process.

Asunto(s)

Lisosomas; Biogénesis de Organelos; Proteínas de Unión al GTP rab; Lisosomas/metabolismo; Proteínas de Unión al GTP rab/metabolismo; Proteínas de Unión al GTP rab/genética; Humanos; Animales; Orgánulos/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biogénesis de Organelos / Proteínas de Unión al GTP rab / Lisosomas Límite: Animals / Humans Idioma: En Revista: J Cell Biol Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos

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