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Interaction of MMP-9 in the active phase of Graves' disease with and without ophthalmopathy.
Minatel Riguetto, Cinthia; Barbosa, Eduardo Buzolin; Atihe, Camila Cristina; Reis, Fabiano; Alves, Monica; Zantut-Wittmann, Denise Engelbrecht.
Afiliación
  • Minatel Riguetto C; Internal Medicine, Universidade Estadual de Campinas, Campinas, Brazil.
  • Barbosa EB; Universidade Estadual de Campinas, Brazil.
  • Atihe CC; Universidade Estadual de Campinas, Brazil.
  • Reis F; Universidade Estadual de Campinas, Brazil.
  • Alves M; Universidade Estadual de Campinas, Brazil.
  • Zantut-Wittmann DE; Universidade Estadual de Campinas, Brazil.
Am J Physiol Endocrinol Metab ; 2024 Sep 11.
Article en En | MEDLINE | ID: mdl-39259164
ABSTRACT

BACKGROUND:

Thyroid eye disease (TED) is expressed as orbital inflammation, and serum levels of several proinflammatory cytokines have been studied among Graves' disease (GD) patients with and without TED; however, a more sensitive and specific marker for the different phases of GD and TED is still lacking.

METHODS:

17 active TED, 16 inactive TED, 16 GD without TED, and 16 healthy controls were recruited. Serum IL-17A, MMP-2, MMP-3, and MMP-9 were measured by multiplex bead assay. TED hormone and eye parameters were evaluated, and their relationship with cytokine levels was analysed.

RESULTS:

Serum MMP-9 was higher in active TED than healthy controls, while IL-17A was lower among these patients than in GD without TED and healthy controls. No differences were found in MMP-3 and MMP-2 concentrations. MMP-9 levels were lower in inactive TED patients who underwent radioactive iodine (RAI) therapy and those on levothyroxine replacement, while MMP-9 levels were elevated in patients on methimazole. A negative correlation was found between age at assessment and time of follow-up with MMP-9 levels in inactive TED. Free T3 and ophthalmometry values were positively correlated with MMP-9 in the GD without TED and inactive TED groups, respectively.

CONCLUSIONS:

Serum MMP-9 was increased in patients with active TED and was related to the RAI treatment, longer follow-up time, and higher ophthalmometry in patients with inactive TED, as well as thyroid function in GD without TED. MMP-9 may be involved in both the active phase of TED and the active phase of inflammation related to GD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Am J Physiol Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos