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Metastatic Cutaneous Squamous Cell Carcinoma in Immunosuppressed Patient: A Systematic Review.
Wackel, Megan; Thomas, Sierra; Schmidt, Cynthia M; Zheng, Cheng; Wysong, Ashley; Whitley, Melodi J.
Afiliación
  • Wackel M; Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Thomas S; Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Schmidt CM; Spencer Fox Eccles School of Medicine, University of Utah Health, Salt Lake City, Utah, USA.
  • Zheng C; Leon S. McGoogan Heath Sciences Library, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Wysong A; Department of Biostatistics, College of Public health, University of Nebraska Medical Center, Omaha, Nebraska, USA.
  • Whitley MJ; Department of Dermatology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
JID Innov ; 4(5): 100294, 2024 Sep.
Article en En | MEDLINE | ID: mdl-39258287
ABSTRACT
Patients who are immunosuppressed, such as solid organ transplant recipients (SOTRs), are at a higher risk of developing cutaneous squamous cell carcinoma (cSCC). This population is at a higher risk of metastasis and worse disease-specific survival. The objective of this review is to better characterize the immunosuppressed population with metastatic cSCC. A literature search was conducted to identify reports of lymphatic metastases in immunosuppressed patients with cSCC. Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed during creation of a cohort with desired inclusion and exclusion criteria. One hundred and thirty-five articles met the inclusion/exclusion criteria, yielding 1020 total cases. We discovered that the most common forms of immunosuppression within the cohort were solid organ transplantation and hematologic malignancy. White males and cSCC tumors involving the head and neck comprised most cases. Using Brigham and Women's Hospital and Eighth edition of American Joint Committee on Cancer tumor staging criteria, we observed a trend toward higher stage tumors in SOTR than in patients with hematologic malignancy. This review confirms that known clinical risk factors for metastatic cSCC appear to be similar among the immunosuppressed population and the cSCC population at large. Interestingly, our data suggest that current staging systems may not accurately reflect metastatic risk among patients with hematologic malignancy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JID Innov Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JID Innov Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos