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Fat Mass and Obesity-Related (FTO) Gene Variant Is a Predictor of CVD in T2DM Patients.
Hussain, Mazhar; Waheed, Akbar; Elahi, Asim; Mustafa, Ghulam.
Afiliación
  • Hussain M; Pharmacology Department Sheikh Zayed Medical College, Rahim Yar Khan, Punjab, Pakistan.
  • Waheed A; Pharmacology Department Riphah International University, Islamabad, Pakistan.
  • Elahi A; Internal Medicine Residency Program South Texas Health GME Consortium Texas A & M School of Medicine, Bryan, Texas, USA.
  • Mustafa G; Community Medicine Department Sheikh Zayed Medical College, Rahim Yar Khan, Punjab, Pakistan.
J Diabetes Res ; 2024: 5914316, 2024.
Article en En | MEDLINE | ID: mdl-39257882
ABSTRACT

Background:

The role of the common FTO gene variant rs9939609 in obesity has been well established, and the FTO gene has a strong association with T2DM.

Objective:

To investigate the association of FTO gene variant rs9939609 with obesity-related parameters in T2DM and CVD patients. Materials and

Methods:

In this cross-sectional study, 280 subjects of either sex aged 45.10 ± 9.6 years were randomly divided into four groups, that is, T2DM, T2DM with CVD, nondiabetic with CVD disease, and normal control. These samples were genotyped by ARMS-PCR. The FTO gene association with obesity-related parameters in T2DM and CVD patients was analyzed by SPSS 22.

Results:

The TT genotype was the most common genotype (46.80%) in our study groups. The minor allele frequency (MAF) was significantly higher in T2DM patients (0.39 vs. 0.28), T2DM patients with CVD (0.43 vs. 0.28), and nondiabetic patients with CVD (0.35 vs. 0.28) as compared to control with p < 0.005. Carriers of the AA genotype of the FTO gene rs9939609 were significantly associated with increased BMI, WC, HbA1C, SBP, DBP, and TGs and lowered HDL cholesterol as compared to the TA and TT genotypes in T2DM and CVD patients with p < 0.005. The FTO gene variant rs9939609 showed a significant association with T2DM and CVD. The AA genotype odds ratio (OR) in T2DM was 1.48 (1.06-2.32), p = 0.006, and in CVD, it was 1.56 (1.04-2.4), p = 0.003.

Conclusion:

The FTO gene variant rs9939609 has a strong association with T2DM and CVD. The AA genotype of FTO gene variants rs9939609 showed a strong association with most of the risk factors of CVD and T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Diabetes Mellitus Tipo 2 / Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato / Frecuencia de los Genes / Obesidad Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Res Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Predisposición Genética a la Enfermedad / Polimorfismo de Nucleótido Simple / Diabetes Mellitus Tipo 2 / Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato / Frecuencia de los Genes / Obesidad Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Diabetes Res Año: 2024 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido