Your browser doesn't support javascript.
loading
Pulmonary Hypertension and Right Ventricle: A Pathophysiological Insight.
Namazi, Mehrshad; Eftekhar, Seyed Parsa; Mosaed, Reza; Shiralizadeh Dini, Saeed; Hazrati, Ebrahim.
Afiliación
  • Namazi M; Trauma and Surgery Research Center, AJA University of Medical Sciences, Tehran, Iran.
  • Eftekhar SP; Clinical Biomechanics and Ergonomics Research Center, AJA University of Medical Sciences, Tehran, Iran.
  • Mosaed R; Trauma and Surgery Research Center, AJA University of Medical Sciences, Tehran, Iran.
  • Shiralizadeh Dini S; Trauma and Surgery Research Center, AJA University of Medical Sciences, Tehran, Iran.
  • Hazrati E; Trauma and Surgery Research Center, AJA University of Medical Sciences, Tehran, Iran.
Clin Med Insights Cardiol ; 18: 11795468241274744, 2024.
Article en En | MEDLINE | ID: mdl-39257563
ABSTRACT

Background:

Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by elevated pulmonary vascular pressure. Long-term PH, irrespective of its etiology, leads to increased right ventricular (RV) pressure, RV hypertrophy, and ultimately, RV failure. Main body Research indicates that RV failure secondary to hypertrophy remains the primary cause of mortality in pulmonary arterial hypertension (PAH). However, the impact of PH on RV structure and function under increased overload remains incompletely understood. Several mechanisms have been proposed, including extracellular remodeling, RV hypertrophy, metabolic disturbances, inflammation, apoptosis, autophagy, endothelial-to-mesenchymal transition, neurohormonal dysregulation, capillary rarefaction, and ischemia.

Conclusions:

Studies have demonstrated the significant role of oxidative stress in the development of RV failure. Understanding the interplay among these mechanisms is crucial for the prevention and management of RV failure in patients with PH.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Med Insights Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Clin Med Insights Cardiol Año: 2024 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Estados Unidos