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foxl2l is a germ cell-intrinsic gatekeeper of oogenesis in zebrafish.
Ren, Zhiqin; Ye, Ding; Su, Naike; Wang, Chaofan; He, Lijia; Wang, Houpeng; He, Mudan; Sun, Yonghua.
Afiliación
  • Ren Z; Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Hubei Hongshan Laboratory, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan, Hubei 430072, China.
  • Ye D; Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Hubei Hongshan Laboratory, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan, Hubei 430072, China.
  • Su N; School of Marine Biology and Fisheries, Hainan University, Haikou, Hainan 570228, China.
  • Wang C; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
  • He L; College of Fisheries and Life Science, Dalian Ocean University, Dalian, Liaoning 116023, China. E-mail: yeding@ihb.ac.cn.
  • Wang H; Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Hubei Hongshan Laboratory, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan, Hubei 430072, China.
  • He M; College of Advanced Agricultural Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
  • Sun Y; Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Hubei Hongshan Laboratory, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan, Hubei 430072, China.
Zool Res ; 45(5): 1116-1130, 2024 Sep 18.
Article en En | MEDLINE | ID: mdl-39257375
ABSTRACT
Zebrafish serve as a valuable model organism for studying germ cell biology and reproductive processes. The AB strain of zebrafish is proposed to exhibit a polygenic sex determination system, where most males initially develop juvenile ovaries before committing to male fate. In species with chromosomal sex determination, gonadal somatic cells are recognized as key determinants of germ cell fate. Notably, the loss of germ cells in zebrafish leads to masculinization, implying that germ cells harbor an intrinsic feminization signal. However, the specific signal triggering oogenesis in zebrafish remains unclear. In the present study, we identified foxl2l as an oocyte progenitor-specific gene essential for initiating oogenesis in germ cells. Results showed that foxl2l-knockout zebrafish bypassed the juvenile ovary stage and exclusively developed into fertile males. Further analysis revealed that loss of foxl2l hindered the initiation of oocyte-specific meiosis and prevented entry into oogenesis, leading to premature spermatogenesis during early gonadal development. Furthermore, while mutation of the pro-male gene dmrt1 led to fertile female differentiation, simultaneous disruption of foxl2l in dmrt1 mutants completely blocked oogenesis, with a large proportion of germ cells arrested as germline stem cells, highlighting the crucial role of foxl2l in oogenesis. Overall, this study highlights the unique function of foxl2l as a germ cell-intrinsic gatekeeper of oogenesis in zebrafish.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oogénesis / Pez Cebra / Proteínas de Pez Cebra Límite: Animals Idioma: En Revista: Zool Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oogénesis / Pez Cebra / Proteínas de Pez Cebra Límite: Animals Idioma: En Revista: Zool Res Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: China