Your browser doesn't support javascript.
loading
The impact of stroke and bleeding on mortality and quality of life during the first year after TAVI: A POPular TAVI subanalysis.
van Nuland, Puck J A; van Ginkel, Dirk Jan; Overduin, Daniel C; Bor, Willem L; Brouwer, Jorn; Nijenhuis, Vincent J; Peper, Joyce; Van't Hof, Arnoud W J; Vriesendorp, Pieter A; Ten Berg, Jurriën M.
Afiliación
  • van Nuland PJA; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • van Ginkel DJ; Faculty of Health, Medicine and Life Sciences (FHML), University Maastricht, Maastricht, The Netherlands.
  • Overduin DC; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Bor WL; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Brouwer J; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Nijenhuis VJ; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Peper J; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Van't Hof AWJ; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
  • Vriesendorp PA; Department of Cardiology, Maastricht University Medical Centre, Maastricht, The Netherlands.
  • Ten Berg JM; Department of Cardiology, Zuyderland Medical Centre, Heerlen, The Netherlands.
Catheter Cardiovasc Interv ; 2024 Sep 11.
Article en En | MEDLINE | ID: mdl-39257293
ABSTRACT

BACKGROUND:

Bleeding and stroke are frequent complications after transcatheter aortic valve implantation (TAVI). The mortality risk associated with these events has been reported before, but data regarding their impact on health-related quality of life (QoL) is limited.

AIM:

To evaluate the impact of bleeding and stroke occurring within 30 days after TAVI, on mortality and QoL during the first year after TAVI.

METHODS:

POPular TAVI was a randomized clinical trial that evaluated the addition of clopidogrel to aspirin or oral anticoagulation in patients undergoing TAVI. Besides clinical outcomes, QoL was assessed using the Short Form-12 and EuroQoL Five Dimensions questionnaires before, and at 3, 6, and 12 months after TAVI.

RESULTS:

Major or life-threatening bleeding occurred in 81 patients (8.3%) and was associated with an increased risk of death (hazard ratio [HR] 1.95 [95% confidence interval (CI) 1.00-3.79]); minor bleeding occurred in 104 patients (10.6%) and was not associated with mortality (HR 0.75 [95% CI 0.30-1.89]). Stroke occurred in 35 patients (3.6%) and was associated with an increased risk of death (HR 2.90 [95% CI 1.23-6.83]). Mean mental component summary (MCS-12) scores over time were lower in patients with major or life-threatening bleeding (p = 0.01), and similar in patients with minor bleeding, compared to patients without bleeding; mean physical component summary (PCS-12) scores, EQ-5D index, and visual analog scale (VAS) were similar between those patients. Mean MCS-12 scores were lower in patients with stroke (p = 0.01), mean PCS-12, EQ-5D index, and VAS were similar compared to patients without stroke.

CONCLUSION:

Major or life-threatening bleeding and stroke were associated with an increased risk of death and decreased mental QoL in the first year after TAVI.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Catheter Cardiovasc Interv Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Catheter Cardiovasc Interv Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos