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Heart failure in Europe: Guideline-directed medical therapy use and decision making in chronic and acute, pre-existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction - the ESC EORP Heart Failure III Registry.
Lund, Lars H; Crespo-Leiro, Maria Generosa; Laroche, Cécile; Zaliaduonyte, Diana; Saad, Aly M; Fonseca, Candida; Celutkiene, Jelena; Zdravkovic, Marija; Bielecka-Dabrowa, Agata M; Agostoni, Piergiuseppe; Xuereb, Robert G; Neronova, Kseniya V; Lelonek, Malgorzata; Cavusoglu, Yuksel; Gellen, Barnabas; Abdelhamid, Magdy; Hammoudi, Naima; Anker, Stefan D; Chioncel, Ovidiu; Filippatos, Gerasimos; Lainscak, Mitja; McDonagh, Theresa A; Mebazaa, Alexandre; Piepoli, Massimo; Ruschitzka, Frank; Seferovic, Petar M; Savarese, Gianluigi; Metra, Marco; Rosano, Giuseppe M C; Maggioni, Aldo P.
Afiliación
  • Lund LH; Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Crespo-Leiro MG; Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
  • Laroche C; Cardiology, Hospital Universitario A Coruña (CHUAC), INIBIC (Institute investigacion Biomedica A Coruña), A Coruña, Spain.
  • Zaliaduonyte D; CIBERCV, A Coruña, Spain.
  • Saad AM; Universidad de A Coruña (UDC), A Coruña, Spain.
  • Fonseca C; European Society of Cardiology, Sophia-Antipolis, France.
  • Celutkiene J; Academy of Medicine, Department of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Zdravkovic M; Department of Cardiology, Kaunas Hospital, Kaunas, Lithuania.
  • Bielecka-Dabrowa AM; Cardiovascular Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
  • Agostoni P; Heart Failure Clinic, Internal Medicine Department, Hospital Sao Francisco Xavier, ULSLO, Lisbon, Portugal.
  • Xuereb RG; NOVA Medical School, Universidade Nova de Lisboa, Lisbon, Portugal.
  • Neronova KV; Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Vilnius University, Vilnius, Lithuania.
  • Lelonek M; Department of Personalized Medicine, Centre of Innovative Medicine, Vilnius, Lithuania.
  • Cavusoglu Y; University Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia.
  • Gellen B; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Abdelhamid M; Department of Cardiology, Non-Invasive Cardiovascular Imaging, CMR Lab, Belgrade, Serbia.
  • Hammoudi N; Department of Cardiology and Congenital Heart Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
  • Anker SD; Department of Preventive Cardiology and Lipidology, Medical University of Lodz, Lodz, Poland.
  • Chioncel O; Department of Clinical Sciences and Community Health, Cardiovascular Section, University of Milan, Milan, Italy.
  • Filippatos G; Heart Failure Unit, Centro Cardiologico Monzino IRCCS, Milan, Italy.
  • Lainscak M; Department of Cardiology, Mater Dei Hospital, Msida, Malta.
  • McDonagh TA; Department of Faculty Therapy Named after M.E. Volsky-M.M. Mirrakhimov, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
  • Mebazaa A; Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland.
  • Piepoli M; Department of Cardiology, Eskisehir Osmangazi University, Eskisehir, Turkey.
  • Ruschitzka F; Department of Cardiology, Heart Failure, ELSAN-Polyclinique de Poitiers, Poitiers, France.
  • Seferovic PM; Department of Cardiovascular Medicine, Kasr AlAiny, Faculty of Medicine, Cairo University, Cairo, Egypt.
  • Savarese G; Department of Cardiology, EHS Maouche Hospital-Benaknoun, Algiers, Algeria.
  • Metra M; Department of Cardiology (CVK), German Heart Center Charité, Berlin, Germany.
  • Rosano GMC; Berlin Institute of Health Center for Regenerative Therapies (BCRT), Berlin, Germany.
  • Maggioni AP; German Centre for Cardiovascular Research (DZHK), Berlin, Germany.
Eur J Heart Fail ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39257278
ABSTRACT

AIMS:

We analysed baseline characteristics and guideline-directed medical therapy (GDMT) use and decisions in the European Society of Cardiology (ESC) Heart Failure (HF) III Registry. METHODS AND

RESULTS:

Between 1 November 2018 and 31 December 2020, 10 162 patients with acute HF (AHF, 39%, age 70 [62-79], 36% women) or outpatient visit for HF (61%, age 66 [58-75], 33% women), with HF with reduced (HFrEF, 57%), mildly reduced (HFmrEF, 17%) or preserved (HFpEF, 26%) ejection fraction were enrolled from 220 centres in 41 European or ESC-affiliated countries. With AHF, 97% were hospitalized, 2.2% received intravenous treatment in the emergency department, and 0.9% received intravenous treatment in an outpatient clinic. AHF was seen by most by a general cardiologist (51%) and outpatient HF most by a HF specialist (48%). A majority had been hospitalized for HF before, but 26% of AHF and 6.1% of outpatient HF had de novo HF. Baseline use, initiation and discontinuation of GDMT varied according to AHF versus outpatient HF, de novo versus pre-existing HF, and by ejection fraction. After the AHF event or outpatient HF visit, use of any renin-angiotensin system inhibitor, angiotensin receptor-neprilysin inhibitor, beta-blocker, mineralocorticoid receptor antagonist and loop diuretics was 89%, 29%, 92%, 78%, and 85% in HFrEF; 89%, 9.7%, 90%, 64%, and 81% in HFmrEF; and 77%, 3.1%, 80%, 48%, and 80% in HFpEF.

CONCLUSION:

Use and initiation of GDMT was high in cardiology centres in Europe, compared to previous reports from cohorts and registries including more primary care and general medicine and regions more local or outside of Europe and ESC-affiliated countries.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Heart Fail Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Eur J Heart Fail Asunto de la revista: CARDIOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido