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Deep learning Radiomics Based on Two-Dimensional Ultrasound for Predicting the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer.
Wang, Zhan; Li, Xiaoqin; Zhang, Heng; Duan, Tongtong; Zhang, Chao; Zhao, Tong.
Afiliación
  • Wang Z; Jintan Peoples Hospital, Jiangsu, Changzhou, China.
  • Li X; Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Zhang H; Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Duan T; Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Zhang C; Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
  • Zhao T; Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Jiangsu, Changzhou, China.
Ultrason Imaging ; : 1617346241276168, 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39257175
ABSTRACT
We investigate the predictive value of a comprehensive model based on preoperative ultrasound radiomics, deep learning, and clinical features for pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for the breast cancer. We enrolled 155 patients with pathologically confirmed breast cancer who underwent NAC. The patients were randomly divided into the training set and the validation set in the ratio of 73. The deep learning and radiomics features of pre-treatment ultrasound images were extracted, and the random forest recursive elimination algorithm and the least absolute shrinkage and selection operator were used for feature screening and DL-Score and Rad-Score construction. According to multifactorial logistic regression, independent clinical predictors, DL-Score, and Rad-Score were selected to construct the comprehensive prediction model DLRC. The performance of the model was evaluated in terms of its predictive effect, and clinical practicability. Compared to the clinical, radiomics (Rad-Score), and deep learning (DL-Score) models, the DLRC accurately predicted the pCR status, with an area under the curve (AUC) of 0.937 (95%CI 0.895-0.970) in the training set and 0.914 (95%CI 0.838-0.973) in the validation set. Moreover, decision curve analysis confirmed that the DLRC had the highest clinical value among all models. The comprehensive model DLRC based on ultrasound radiomics, deep learning, and clinical features can effectively and accurately predict the pCR status of breast cancer after NAC, which is conducive to assisting clinical personalized diagnosis and treatment plan.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ultrason Imaging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Ultrason Imaging Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido