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Helicobacter pylori seropositivity associates with hyperglycemia, but not obesity, in Danish children and adolescents.
Kløve, Sigri; Stinson, Sara E; Romme, Fie O; Butt, Julia; Graversen, Katrine B; Lund, Morten A V; Fonvig, Cilius E; Waterboer, Tim; Perez-Perez, Guillermo I; Hansen, Torben; Holm, Jens-Christian; Andersen, Sandra B.
Afiliación
  • Kløve S; Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 1353, Denmark. sigri.kloeve@sund.ku.dk.
  • Stinson SE; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Romme FO; Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 1353, Denmark.
  • Butt J; Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Graversen KB; Center for Evolutionary Hologenomics, Globe Institute, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 1353, Denmark.
  • Lund MAV; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Fonvig CE; The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Pediatrics, Holbæk Hospital, Holbæk, 4300, Denmark.
  • Waterboer T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Perez-Perez GI; The Children's Obesity Clinic, accredited European Centre for Obesity Management, Department of Pediatrics, Holbæk Hospital, Holbæk, 4300, Denmark.
  • Hansen T; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
  • Holm JC; Infections and Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
  • Andersen SB; School of Medicine, New York University, New York, NY, 10016, USA.
BMC Med ; 22(1): 379, 2024 Sep 11.
Article en En | MEDLINE | ID: mdl-39256870
ABSTRACT

BACKGROUND:

Helicobacter pylori colonizes the human stomach and may affect the inflammatory response, hormone production related to energy regulation, and gastrointestinal microbiota composition. Previous studies have explored a potential association between H. pylori infection and pediatric obesity with varying results. Considering the immunomodulatory effects of early-life infection with H. pylori that can confer beneficial effects, we hypothesized that we would find an inverse relationship between H. pylori seropositivity and obesity among Danish children and adolescents.

METHODS:

We assessed H. pylori seroprevalence in 713 subjects from an obesity clinic cohort and 990 subjects from a population-based cohort, aged 6 to 19 years, and examined its association with obesity and other cardiometabolic risk factors.

RESULTS:

No association was found between H. pylori and body mass index standard deviation score (BMI SDS). H. pylori seropositivity was, however, significantly associated with higher fasting plasma glucose levels and the prevalence of hyperglycemia.

CONCLUSION:

While we did not find an association between H. pylori seropositivity and BMI SDS, we observed a significant association with higher fasting plasma glucose levels and increased prevalence of hyperglycemia, suggesting that H. pylori infection may contribute to impaired glucose regulation in Danish children and adolescents.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Hiperglucemia Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: BMC Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Hiperglucemia Límite: Adolescent / Adult / Child / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: BMC Med Asunto de la revista: MEDICINA Año: 2024 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido