Your browser doesn't support javascript.
loading
Molecular Investigation of the Self-Assembly Mechanism Underlying Polydopamine Coatings: The Synergistic Effect of Typical Building Blocks Acting on Interfacial Adhesion.
Li, Xiguang; Wu, Chunya; Wu, Jiahao; Sun, Ruijiang; Hou, Bo; Liu, Chang; Chen, Mingjun.
Afiliación
  • Li X; State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
  • Wu C; School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
  • Wu J; State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
  • Sun R; School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
  • Hou B; Key Laboratory of Micro-systems and Micro-structures Manufacturing, Harbin Institute of Technology, Harbin, Heilongjiang 150080, China.
  • Liu C; State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
  • Chen M; School of Mechatronics Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
ACS Appl Mater Interfaces ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39256056
ABSTRACT
Polydopamine (PDA) is well known as a mussel-inspired adhesive material composed of oligomeric heteropolymers. However, the conventional eumelanin-like structural assumption of PDA seems deficient in explaining its interfacial adhesion. To determine the decisive mechanism of PDA coating formation, experiments and simulations were performed in this study. 5,6-Dihydroxyindole (DHI), the signature building block of eumelanin, was introduced as the control group. Various typical building blocks in PDA were quantified by physicochemical characterizations, and the polar-group-dominated interfacial interaction was evaluated by classic molecular dynamics and metadynamics methods. Aminoethyl has been proven to be the key functional group inducing the adsorption of PDA on the hydroxylated silica substrates, while DHI shows limited adhesion to the substrate due to the absence of aminoethyl as the catechol-indole structure of DHI exhibits poor affinity to the silica surface. Pyrrole carboxylic acid, as an oxidative product detected from PDA/DHI, is unfavorable for its adhesion to silica substrates. Overall, the coating formation and self-aggregating precipitation of PDA are two competitive aminoethyl-consuming paths; thus, the in situ oxidative coupling of dopamine is indispensable for the PDA coating preparation. The collected PDA precipitates can no longer present satisfactory coating forming behavior, resulting from a shortage of aminoethyl moieties.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos