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Functional connectivity of the amygdala in relation to high stress and low mindfulness.
Kim, Heeyeon; Jeon, Min-Jeong; Seong, Goeun; Jung, Young-Chul; Park, Jin Young; Lee, Deokjong.
Afiliación
  • Kim H; Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, South Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul 03722, South Korea.
  • Jeon MJ; Department of Clinical Psychology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, South Korea.
  • Seong G; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul 03722, South Korea.
  • Jung YC; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul 03722, South Korea; Department of Psychiatry, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, South Korea; Institute for Innovation in Digital Healthcare, Yonsei University, Seoul 03722,
  • Park JY; Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin 16995, South Korea; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul 03722, South Korea. Electronic address: empathy@yuhs.ac.
  • Lee D; Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul 03722, South Korea; Yongin Empathy Psychiatry Clinic, Seoul 07008, South Korea. Electronic address: pangelt20@gmail.com.
Neurosci Lett ; 842: 137985, 2024 Nov 01.
Article en En | MEDLINE | ID: mdl-39255895
ABSTRACT

BACKGROUND:

High psychological stress has been associated with several brain functional changes, including functional connectivity (FC) alterations in regions such as the prefrontal cortex and the amygdala. This study explored FC alterations associated with high perceived stress, and also investigated whether these neuroimaging features were correlated with low levels of mindfulness.

METHODS:

This study included 29 adults (12 males and 17 females; mean age 27.6 ± 3.2) who complained of moderate or higher perceived stress and 31 adults (17 males and 14 females; mean age 29.2 ± 7.2) who complained of low-level stress on the questionnaire scale. Seed-based resting-state FC analysis was conducted to compare between high and low stress groups. The dorsolateral prefrontal cortex (DLPFC), the ventromedial prefrontal cortex (VMPFC) and the amygdala were selected as seeds.

RESULTS:

High stress group showed weaker left amygdala-based FC in the left cerebellum crus II and the left orbitofrontal cortex compared with low stress group. High stress group had weaker FC between the left DLPFC and the left inferior parietal lobule. On the contrary, high stress group had stronger FC between the left VMPFC and the left caudate compared with low stress group. Weaker FC between the amygdala and the cerebellum crus II was correlated with lower level of awareness facet of mindfulness.

CONCLUSIONS:

Those with high perceived stress showed low levels of mindfulness and several FC alterations centered on the prefrontal cortex and amygdala. Our findings also suggest that weak amygdala-based FC alterations associated with high psychological stress are related to low-level awareness facet of mindfulness.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Imagen por Resonancia Magnética / Atención Plena / Amígdala del Cerebelo Límite: Adult / Female / Humans / Male Idioma: En Revista: Neurosci Lett Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Imagen por Resonancia Magnética / Atención Plena / Amígdala del Cerebelo Límite: Adult / Female / Humans / Male Idioma: En Revista: Neurosci Lett Año: 2024 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Irlanda