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Retrospective Analysis of Blood Biomarkers of Neurological Injury in Human Cases of Viral Infection and Bacterial Sepsis.
Bartlett, Maggie L; Goux, Heather; Johnson, Linwood; Schully, Kevin L; Gregory, Melissa; Brandsma, Joost; Chenoweth, Josh G; Clark, Danielle V; Rivera, Luis Felipe; Lezcano-Coba, Carlos; Vittor, Amy Y; Hayes, Ronald; Galué, Josefrancisco; Carrera, Jean-Paul; Smith, Darci R.
Afiliación
  • Bartlett ML; Naval Medical Research Command, Biological Defense Research Directorate, Microbiology and Immunology Department; Ft. Detrick, MD, USA.
  • Goux H; Parsons Corporation, Health and Biosciences; Centreville, VA, USA.
  • Johnson L; Naval Medical Research Command, Biological Defense Research Directorate, Microbiology and Immunology Department; Ft. Detrick, MD, USA.
  • Schully KL; Parsons Corporation, Health and Biosciences; Centreville, VA, USA.
  • Gregory M; Naval Medical Research Command, Biological Defense Research Directorate, Microbiology and Immunology Department; Ft. Detrick, MD, USA.
  • Brandsma J; Parsons Corporation, Health and Biosciences; Centreville, VA, USA.
  • Chenoweth JG; Naval Medical Research Command, Biological Defense Research Directorate, ACESO Department; Ft. Detrick, MD, USA.
  • Clark DV; The Austere environments Consortium for Enhanced Sepsis Outcomes, The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.
  • Rivera LF; The Austere environments Consortium for Enhanced Sepsis Outcomes, The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.
  • Lezcano-Coba C; The Austere environments Consortium for Enhanced Sepsis Outcomes, The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.
  • Vittor AY; The Austere environments Consortium for Enhanced Sepsis Outcomes, The Henry M. Jackson Foundation for the Advancement of Military Medicine Inc., Bethesda, MD, USA.
  • Hayes R; Gorgas Memorial Institute, Panama City, Panama.
  • Galué J; Carson Centre for Health and Ecosystems Research, La Peñita, Darién, Panama.
  • Carrera JP; Gorgas Memorial Institute, Panama City, Panama.
  • Smith DR; Carson Centre for Health and Ecosystems Research, La Peñita, Darién, Panama.
J Infect Dis ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39255068
ABSTRACT

BACKGROUND:

Blood biomarkers of neurological injury could provide a rapid diagnosis of central nervous system (CNS) injury caused by infections. An FDA-approved assay for mild traumatic brain injury (TBI) measures glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), which signal astrocyte and neuronal injury, respectively. Here, we assessed the applicability of this biomarker assay for determining infection-induced brain injury.

METHODS:

We measured serum levels of GFAP and UCH-L1 retrospectively in serum samples from three study populations 1) human cases infected with Venezuelan equine encephalitis virus (VEEV) and Madariaga virus (MADV) (n = 73), 2) human sepsis patients who were severely ill or diagnosed with encephalitis (n = 66), and 3) sepsis cases that were subsequently evaluated for cognitive impairment (n = 64).

RESULTS:

In the virus infection group, we found elevated GFAP for VEEV (p = 0.014) and MADV (p = 0.011) infections, which correlated with seizures (p = 0.006). In the bacterial sepsis group, GFAP was elevated in cases diagnosed with encephalitis (p = 0.0007) and correlated with headaches (p = 0.0002). In the bacterial sepsis cases with a later cognitive assessment, elevated GFAP (p = 0.0057) at study enrollment was associated with cognitive impairment six months later with a positive prognostic capacity of 79% (CI 66-95%; p = 0.0068).

CONCLUSIONS:

GFAP and UCH-L1 levels measured using an FDA-approved assay for TBI may indicate brain injury resulting from viral or bacterial infections and could predict the development of neurological sequelae.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Infect Dis Año: 2024 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos