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Multisample lipidomic profiles of irritable bowel syndrome and irritable bowel syndrome-like symptoms in patients with inflammatory bowel disease: new insight into the recognition of the same symptoms in different diseases.
Chen, Guorong; Wu, Xuan; Zhu, Huiting; Li, Kemin; Zhang, Junhai; Sun, Shijie; Wang, Huifen; Wang, Miao; Shao, Bing; Li, Hui; Zhang, Yanli; Du, Shiyu.
Afiliación
  • Chen G; Department of Gastroenterology, China-Japan Friendship Hospital(Institute of Clinical Medical Sciences), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100029, China.
  • Wu X; School of Public Health, Capital Medical University, Beijing, 100069, China.
  • Zhu H; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, 100013, China.
  • Li K; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China.
  • Zhang J; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China.
  • Sun S; Department of Gastroenterology, China-Japan Friendship Hospital(Institute of Clinical Medical Sciences), Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100029, China.
  • Wang H; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China.
  • Wang M; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China.
  • Shao B; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China.
  • Li H; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, 100013, China.
  • Zhang Y; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, 100013, China.
  • Du S; Department of Gastroenterology, China-Japan Friendship Hospital, Beijing, 100029, China. 13521234067@163.com.
J Gastroenterol ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39254836
ABSTRACT

BACKGROUND:

Overlapping clinical manifestations of irritable bowel syndrome (IBS) and IBS-like symptoms in patients with inflammatory bowel disease (IBD-IBS) present challenges in diagnosis and management. Both conditions are associated with alterations in metabolites, but few studies have described the lipid profiles. Our aim was to pinpoint specific lipids that contribute to the pathogenesis of IBS and IBD-IBS by analyzing multiple biologic samples.

METHODS:

Diarrhea-predominant IBS (IBS-D) patients (n = 39), ulcerative colitis in remission with IBS-like symptoms patients (UCR-IBS) (n = 21), and healthy volunteers (n = 35) were recruited. IBS-D patients meet the Rome IV diagnostic criteria, and UCR-IBS patients matched mayo scores ≤ two points and Rome IV diagnostic criteria. Serum, feces, and mucosa were collected for further analysis. Lipid extraction was carried out by ultra-performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS).

RESULTS:

Lipidomics of mucosa and serum samples significantly differed among the three groups. Feces showed the most altered lipid species, and the enrichment analysis of 347 differentially abundant metabolites via KEGG pathway analysis revealed that alpha-linolenic acid metabolism was significantly altered in the two groups (P < 0.01). The ratio of omega-6/omega-3 fatty acid were imbalance in serum samples.

CONCLUSIONS:

This study revealed a comprehensive lipid composition pattern between IBS-D patients and UCR-IBS patients. We found several distinctive lipids involved in alpha-linolenic acid metabolism, reflecting an imbalance in the omega-6/omega-3 fatty acid ratio. Compared to mucosa and serum samples, fecal samples might have more advantages in lipidomics studies due to the convenience of sample collection and effectiveness in reflecting metabolic information.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China Pais de publicación: Japón