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Risk-reducing surgeries for breast cancer in Brazilian patients undergoing multigene germline panel: impact of results on decision making.
Duarte, Bárbara Narciso; Alem, Christine Elisabete Rubio; da Silva Cabello, Ana Elisa Ribeiro; Teixeira, Sandra Regina Campos; Cabello, Cesar.
Afiliación
  • Duarte BN; Faculdade de Ciências Médicas da UNICAMP, Departamento de Tocoginecologia da FCM/UNICAMP, Universidade Estadual de Campinas, Rua Alexander Fleming, 101. Cidade Universitária 13081-940, Campinas, SP, Brasil.
  • Alem CER; Faculdade de Ciências Médicas da UNICAMP, Departamento de Tocoginecologia da FCM/UNICAMP, Universidade Estadual de Campinas, Rua Alexander Fleming, 101. Cidade Universitária 13081-940, Campinas, SP, Brasil.
  • da Silva Cabello AER; Faculdade de Ciências Médicas da UNICAMP, Departamento de Tocoginecologia da FCM/UNICAMP, Universidade Estadual de Campinas, Rua Alexander Fleming, 101. Cidade Universitária 13081-940, Campinas, SP, Brasil.
  • Teixeira SRC; Faculdade de Ciências Médicas da UNICAMP, Departamento de Tocoginecologia da FCM/UNICAMP, Universidade Estadual de Campinas, Rua Alexander Fleming, 101. Cidade Universitária 13081-940, Campinas, SP, Brasil.
  • Cabello C; Faculdade de Ciências Médicas da UNICAMP, Departamento de Tocoginecologia da FCM/UNICAMP, Universidade Estadual de Campinas, Rua Alexander Fleming, 101. Cidade Universitária 13081-940, Campinas, SP, Brasil. cabello@unicamp.br.
Breast Cancer Res Treat ; 2024 Sep 10.
Article en En | MEDLINE | ID: mdl-39254767
ABSTRACT

PURPOSE:

To assess the behavior change of high-risk breast cancer patients regarding the intention to undergo risk-reducing mastectomies (RRM) before and after genetic testing results and to identify the main influencing factors in decision-making.

METHODS:

Prospective cohort study conducted between November 2021 and October 2022 with women under follow-up at the high-risk outpatient clinic of the State University of Campinas (UNICAMP). Patients were referred for genetic testing, followed by counseling according to the test result.

RESULTS:

A total of 373 women were included. In the pre-genetic testing analysis, 54.1% of patients intended to undergo RRMs. After testing, 42.2% opted for the procedure. Behavior change occurred in 26.2%, mainly from "yes" to "no/don't know" (72,6%) (p < 0.001). The genetic test result was positive (LPV or PV) in 29.7% of patients. Among the 90 patients with positive results, 62 (68.9%) agreed to RRM, while 22 (24.4%) remained unwilling to accept RRM, regardless of the positive test. Significant influencing factors for behavior change pre- and post-genetic testing (in favor of surgery) in multivariate analysis were positive genetic test result (OR 2.94, p < 0.001), personal cancer history (OR 2.7, p = 0.008), and ages between 40 and 49 years (OR 2.07, p = 0.008) and ≥ 50 years (OR 3.47, p < 0.001).

CONCLUSION:

In a Brazilian population at high-risk for breast cancer and users of the public health system, it was observed that most desired RRM, however, when genetic testing and counseling were performed, behavior change was observed, especially when the result was positive.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE País/Región como asunto: America do sul / Brasil Idioma: En Revista: Breast Cancer Res Treat Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE País/Región como asunto: America do sul / Brasil Idioma: En Revista: Breast Cancer Res Treat Año: 2024 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos