Xanthogranulomatous Pyelonephritis: A pooled quantitative analysis of published cases.
Folia Med Cracov
; 64(1): 63-74, 2024 Jun 30.
Article
en En
| MEDLINE
| ID: mdl-39254583
ABSTRACT
Xanthogranulomatous Pyelonephritis (XGP) is a serious and rare inflammatory disease of unknown etiology. This systematic review analyzes XGP cases. We performed a literature search for "Pyelonephritis, Xanthogranulomatous." The primary composite outcome was recovery with post-surgery complications, partial recovery, death, or chronic kidney disease. The secondary outcome was any presentation or treatment complication. Predictor variables consisted of demographics, history, symptoms, and diagnosis/management. Among the 251 patients, the mean age was 36.1 years, and 57.4% were female. The most common symptom and finding were fever (55.0%) and renal stones (53.8%), respectively. There were 15.5% with the composite outcome. There were 51.0% with any presentation or treatment complication. Multivariate logistic regression analysis for the composite outcome showed that kidney of both/horseshoe (OR3.86, 95% CI1.01, 14.73, p = 0.048), dialysis required (OR8.64, 95% CI2.27, 32.94, p = 0.002), and operative treatment of nephrostomy or nephrostomy followed by nephrectomy (OR4.57, 95% CI1.58, 13.17, p = 0.01) were each significantly associated with increased odds. Fever (OR3.04, 95% CI1.63, 5.67, p <0.001) and renal stones (OR2.55, 95% CI1.35, 4.81, p = 0.004) were each significantly associated with increased odds for any presentation/treatment complication. In conclusion, XGP patients with involvement of both or horseshoe kidneys, dialysis requirements, or treatment of nephrostomy or nephrostomy followed by nephrectomy may require aggressive treatment to mitigate poor patient outcomes.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pielonefritis Xantogranulomatosa
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Folia Med Cracov
Año:
2024
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Polonia